1jes

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[[Image:1jes.gif|left|200px]]
[[Image:1jes.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1jes |SIZE=350|CAPTION= <scene name='initialview01'>1jes</scene>, resolution 1.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1jes", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DPY:2-DEOXYRIBOFURANOSYL-PYRIDINE-2,6-DICARBOXYLIC+ACID-5&#39;-MONOPHOSPHATE'>DPY</scene>, <scene name='pdbligand=DRP:2-DEOXYRIBOFURANOSYL-PYRIDINE-5&#39;-MONOPHOSPHATE'>DRP</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1jes| PDB=1jes | SCENE= }}
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|RELATEDENTRY=[[1bna|1BNA]], [[2zna|2ZNA]], [[3zna|3ZNA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jes OCA], [http://www.ebi.ac.uk/pdbsum/1jes PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jes RCSB]</span>
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}}
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'''Crystal Structure of a Copper-Mediated Base Pair in DNA'''
'''Crystal Structure of a Copper-Mediated Base Pair in DNA'''
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==About this Structure==
==About this Structure==
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1JES is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JES OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JES OCA].
==Reference==
==Reference==
Structure of a copper-mediated base pair in DNA., Atwell S, Meggers E, Spraggon G, Schultz PG, J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11734038 11734038]
Structure of a copper-mediated base pair in DNA., Atwell S, Meggers E, Spraggon G, Schultz PG, J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11734038 11734038]
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[[Category: Protein complex]]
 
[[Category: Atwell, S.]]
[[Category: Atwell, S.]]
[[Category: Meggers, E.]]
[[Category: Meggers, E.]]
[[Category: Schultz, P G.]]
[[Category: Schultz, P G.]]
[[Category: Spraggon, G.]]
[[Category: Spraggon, G.]]
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[[Category: copper]]
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[[Category: Copper]]
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[[Category: cu]]
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[[Category: Cu]]
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[[Category: designed]]
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[[Category: Designed]]
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[[Category: dna]]
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[[Category: Dna]]
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[[Category: dodecamer]]
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[[Category: Dodecamer]]
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[[Category: duplex]]
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[[Category: Duplex]]
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[[Category: metal]]
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[[Category: Metal]]
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[[Category: unnatural]]
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[[Category: Unnatural]]
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[[Category: z-dna]]
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[[Category: Z-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:08:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:32:44 2008''
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Revision as of 18:08, 2 May 2008

Image:1jes.gif

Template:STRUCTURE 1jes

Crystal Structure of a Copper-Mediated Base Pair in DNA


Overview

Stable and selective DNA base pairing by metal coordination was recently demonstrated with nucleotides containing complementary pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.; Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am. Chem. Soc. 2000, 122, 10714-10715). To understand the structural consequences of introducing this novel base pair into DNA we have solved the crystal structure of a duplex containing the metallo-base pair. The structure shows that the bases pair as designed, but in a Z-DNA conformation. The structure also provides a structural explanation for the B- to Z-DNA transition in this duplex. Further solution studies demonstrate that the metallo-base pair is compatible with Z- or B-DNA conformations, depending on the duplex sequence.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of a copper-mediated base pair in DNA., Atwell S, Meggers E, Spraggon G, Schultz PG, J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:11734038 Page seeded by OCA on Fri May 2 21:08:09 2008

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