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1jfi

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[[Image:1jfi.gif|left|200px]]
[[Image:1jfi.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1jfi |SIZE=350|CAPTION= <scene name='initialview01'>1jfi</scene>, resolution 2.62&Aring;
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The line below this paragraph, containing "STRUCTURE_1jfi", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= NC2 alpha (DRAP1) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), NC2 beta (Dr1) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), tbp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5150 COG5150], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5247 BUR6], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04516 TBP_eukaryotes], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2101 SPT15]</span>
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{{STRUCTURE_1jfi| PDB=1jfi | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfi OCA], [http://www.ebi.ac.uk/pdbsum/1jfi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jfi RCSB]</span>
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}}
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'''Crystal Structure of the NC2-TBP-DNA Ternary Complex'''
'''Crystal Structure of the NC2-TBP-DNA Ternary Complex'''
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[[Category: Shu, F.]]
[[Category: Shu, F.]]
[[Category: Stelzer, G.]]
[[Category: Stelzer, G.]]
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[[Category: h2a/h2b]]
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[[Category: H2a/h2b]]
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[[Category: histone]]
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[[Category: Histone]]
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[[Category: nc2]]
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[[Category: Nc2]]
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[[Category: negative cofactor]]
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[[Category: Negative cofactor]]
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[[Category: new york structural genomix research consortium]]
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[[Category: New york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: Nysgxrc]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: tata-dna]]
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[[Category: Tata-dna]]
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[[Category: tbp]]
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[[Category: Tbp]]
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[[Category: transcription initiation]]
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[[Category: Transcription initiation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:40:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:32:57 2008''
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Revision as of 06:40, 24 April 2008

Image:1jfi.gif

Template:STRUCTURE 1jfi

Crystal Structure of the NC2-TBP-DNA Ternary Complex


Overview

The X-ray structure of a ternary complex of Negative Cofactor 2 (NC2), the TATA box binding protein (TBP), and DNA has been determined at 2.6 A resolution. The N termini of NC2 alpha and beta resemble histones H2A and H2B, respectively, and form a heterodimer that binds to the bent DNA double helix on the underside of the preformed TBP-DNA complex via electrostatic interactions. NC2beta contributes to inhibition of TATA-dependent transcription through interactions of its C-terminal alpha helix with a conserved hydrophobic feature on the upper surface of TBP, which in turn positions the penultimate alpha helix of NC2beta to block recognition of the TBP-DNA complex by transcription factor IIB. Further regulatory implications of the NC2 heterodimer structure are discussed.

About this Structure

1JFI is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 1JFI with [TATA-Binding Protein]. Full crystallographic information is available from OCA.

Reference

Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex., Kamada K, Shu F, Chen H, Malik S, Stelzer G, Roeder RG, Meisterernst M, Burley SK, Cell. 2001 Jul 13;106(1):71-81. PMID:11461703 Page seeded by OCA on Thu Apr 24 09:40:09 2008

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