1jgg
From Proteopedia
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[[Image:1jgg.gif|left|200px]] | [[Image:1jgg.gif|left|200px]] | ||
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'''Even-skipped Homeodomain Complexed to AT-rich DNA''' | '''Even-skipped Homeodomain Complexed to AT-rich DNA''' | ||
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[[Category: Aggarwal, A K.]] | [[Category: Aggarwal, A K.]] | ||
[[Category: Hirsch, J A.]] | [[Category: Hirsch, J A.]] | ||
| - | [[Category: | + | [[Category: Even-skipped]] |
| - | [[Category: | + | [[Category: Homeodomain]] |
| - | [[Category: | + | [[Category: Protein-dna complex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:11:37 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 18:11, 2 May 2008
Even-skipped Homeodomain Complexed to AT-rich DNA
Overview
even-skipped is a homeobox gene important in controlling segment patterning in the embryonic fruit fly. Its homeobox encodes a DNA binding domain which binds with similar affinities to two DNA consensus sequences, one AT-rich, the other GC-rich. We describe a crystallographic analysis of the Even-skipped homeodomain complexed to an AT-rich oligonucleotide at 2.0 A resolution. The structure reveals a novel arrangement of two homeodomains bound to one 10 bp DNA sequence in a tandem fashion. This arrangement suggests a mechanism for the homeoproteins' regulatory specificity. In addition, the functionally important residue Gln50 is observed in multiple conformations making direct and water-mediated hydrogen bonds with the DNA bases.
About this Structure
1JGG is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
Structure of the even-skipped homeodomain complexed to AT-rich DNA: new perspectives on homeodomain specificity., Hirsch JA, Aggarwal AK, EMBO J. 1995 Dec 15;14(24):6280-91. PMID:8557047 Page seeded by OCA on Fri May 2 21:11:37 2008
