1jgs
From Proteopedia
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'''Multiple Antibiotic Resistance Repressor, MarR''' | '''Multiple Antibiotic Resistance Repressor, MarR''' | ||
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[[Category: Mealy, T R.]] | [[Category: Mealy, T R.]] | ||
[[Category: Seaton, B A.]] | [[Category: Seaton, B A.]] | ||
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| - | [[Category: | + | [[Category: Transcription regulation]] |
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Revision as of 18:12, 2 May 2008
Multiple Antibiotic Resistance Repressor, MarR
Overview
MarR is a regulator of multiple antibiotic resistance in Escherichia coli. It is the prototypical member of the MarR family of regulatory proteins found in bacteria and archaea that play important roles in the development of antibiotic resistance, a global health problem. Here we describe the crystal structure of the MarR protein, determined at a resolution of 2.3 A. This is the first reported crystal structure of a member of this newly-described protein family. The structure shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.
About this Structure
1JGS is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution., Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF, Nat Struct Biol. 2001 Aug;8(8):710-4. PMID:11473263 Page seeded by OCA on Fri May 2 21:12:19 2008
