Plectin
From Proteopedia
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<Structure load='1sh6' size='400' caption='Mouse plectin actin-binding domain [[1sh6]]' scene= '> | <Structure load='1sh6' size='400' caption='Mouse plectin actin-binding domain [[1sh6]]' scene= '> | ||
| - | + | == FUNCTION == | |
| - | '''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin<ref>PMID:24810881</ref>, <ref>PMID:24940650</ref>. N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms | + | '''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin<ref>PMID:24810881</ref>, <ref>PMID:24940650</ref>. N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms. |
For more details see [[Group:MUZIC:Plectin]]. | For more details see [[Group:MUZIC:Plectin]]. | ||
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| + | ==Disease == | ||
| + | Mutations in plectin result in skin fragility and blister formation<ref>PMID:15810881</ref>. | ||
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==3D structures of plectin== | ==3D structures of plectin== | ||
Revision as of 08:28, 5 July 2016
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