Poly (ADP-ribose) glycohydrolase
From Proteopedia
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'''Poly (ADP-ribose) glycohydrolase''' (PARG) hydrolizes the ribose-ribose bonds in poly (ADP-ribose). Poly (ADP-ribose) are synthesized after DNA damage. PARG acts as both endo- and exoglycosidase and releases poly (ADP-ribose) of different lengths including monomers<ref>PMID:11376691</ref>. | '''Poly (ADP-ribose) glycohydrolase''' (PARG) hydrolizes the ribose-ribose bonds in poly (ADP-ribose). Poly (ADP-ribose) are synthesized after DNA damage. PARG acts as both endo- and exoglycosidase and releases poly (ADP-ribose) of different lengths including monomers<ref>PMID:11376691</ref>. | ||
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| - | == Disease == | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
| + | The active site of PARG contains two catalytic glutamic acid residues<ref>PMID:21892188</ref>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:57, 5 July 2016
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3D Structures of poly (ADP-ribose) glycohydrolase
Updated on 05-July-2016
References
- ↑ Herceg Z, Wang ZQ. Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. Mutat Res. 2001 Jun 2;477(1-2):97-110. PMID:11376691
- ↑ Virag L, Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev. 2002 Sep;54(3):375-429. PMID:12223530
- ↑ Slade D, Dunstan MS, Barkauskaite E, Weston R, Lafite P, Dixon N, Ahel M, Leys D, Ahel I. The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase. Nature. 2011 Sep 4. doi: 10.1038/nature10404. PMID:21892188 doi:10.1038/nature10404
