1ji3

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[[Image:1ji3.gif|left|200px]]
[[Image:1ji3.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ji3 |SIZE=350|CAPTION= <scene name='initialview01'>1ji3</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1ji3", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1ji3| PDB=1ji3 | SCENE= }}
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|RELATEDENTRY=[[1cvl|1cvl]], [[4lip|4lip]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ji3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji3 OCA], [http://www.ebi.ac.uk/pdbsum/1ji3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ji3 RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE FIRST THERMOSTABLE BACTERIAL LIPASE FROM BACILLUS STEAROTHERMOPHILUS'''
'''CRYSTAL STRUCTURE OF THE FIRST THERMOSTABLE BACTERIAL LIPASE FROM BACILLUS STEAROTHERMOPHILUS'''
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[[Category: Tyndall, J D.A.]]
[[Category: Tyndall, J D.A.]]
[[Category: Walkinshaw, M D.]]
[[Category: Walkinshaw, M D.]]
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[[Category: lipase]]
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[[Category: Lipase]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: thermophilic]]
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[[Category: Thermophilic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:15:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:33:58 2008''
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Revision as of 18:15, 2 May 2008

Image:1ji3.gif

Template:STRUCTURE 1ji3

CRYSTAL STRUCTURE OF THE FIRST THERMOSTABLE BACTERIAL LIPASE FROM BACILLUS STEAROTHERMOPHILUS


Overview

We describe the first lipase structure from a thermophilic organism. It shares less than 20% amino acid sequence identity with other lipases for which there are crystal structures, and shows significant insertions compared with the typical alpha/beta hydrolase canonical fold. The structure contains a zinc-binding site which is unique among all lipases with known structures, and which may play a role in enhancing thermal stability. Zinc binding is mediated by two histidine and two aspartic acid residues. These residues are present in comparable positions in the sequences of certain lipases for which there is as yet no crystal structural information, such as those from Staphylococcal species and Arabidopsis thaliana. The structure of Bacillus stearothermophilus P1 lipase provides a template for other thermostable lipases, and offers insight into mechanisms used to enhance thermal stability which may be of commercial value in engineering lipases for industrial uses.

About this Structure

1JI3 is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a thermostable lipase from Bacillus stearothermophilus P1., Tyndall JD, Sinchaikul S, Fothergill-Gilmore LA, Taylor P, Walkinshaw MD, J Mol Biol. 2002 Nov 8;323(5):859-69. PMID:12417199 Page seeded by OCA on Fri May 2 21:15:01 2008

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