Pre-mRNA-splicing factor
From Proteopedia
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*'''Prp18''' and '''Bud31''' are essential for the catalytic step in pre-mRNA splicing process.<br /> | *'''Prp18''' and '''Bud31''' are essential for the catalytic step in pre-mRNA splicing process.<br /> | ||
*'''snRNA-associated-splicing factor 24''' binds preferentially to the U4/U6 hybrid snRNAs. For details see [[Prp24]]<br /> | *'''snRNA-associated-splicing factor 24''' binds preferentially to the U4/U6 hybrid snRNAs. For details see [[Prp24]]<br /> | ||
| - | *[[Prp19]]<br /> | + | *For '''Prp19''' see [[Prp19]]<br /> |
| - | *[[Prp40]].<br /> | + | *'''Prp31''' functions in forming the U4/U5-U6 tri-snRNP.<br /> |
| + | *For '''Prp40''' see [[Prp40]].<br /> | ||
*'''Prpcwc2''' is a yeast splicing factor which plays a role in the generation of a functional splicing center '''Prp RBM22''' is the human homolog of Prpcwc2.<br /> | *'''Prpcwc2''' is a yeast splicing factor which plays a role in the generation of a functional splicing center '''Prp RBM22''' is the human homolog of Prpcwc2.<br /> | ||
*'''Prpcwc26''' or '''Bud13''' belongs to the pre-mRNA retention and splicing complex RES.<br /> | *'''Prpcwc26''' or '''Bud13''' belongs to the pre-mRNA retention and splicing complex RES.<br /> | ||
| + | |||
| + | == Disease == | ||
| + | Mutations in Prp8 and Prp31 cause retinitis pigmentosa<ref>PMID:11468273</ref>. | ||
== 3D Structures of pre-mRNA splicing factors == | == 3D Structures of pre-mRNA splicing factors == | ||
Revision as of 10:24, 10 July 2016
Contents |
Function
Pre-mRNA-splicing factors (Prp) are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing[1].
- Prp3b is part of the U2 small nuclear ribonucleoproteins complex (U2 snRNP)
- Prp8 functions as a scaffold which mediates the ordered assembly of spliceosomal proteins and snRNAs. For details see Prp8
- Prp18 and Bud31 are essential for the catalytic step in pre-mRNA splicing process.
- snRNA-associated-splicing factor 24 binds preferentially to the U4/U6 hybrid snRNAs. For details see Prp24
- For Prp19 see Prp19
- Prp31 functions in forming the U4/U5-U6 tri-snRNP.
- For Prp40 see Prp40.
- Prpcwc2 is a yeast splicing factor which plays a role in the generation of a functional splicing center Prp RBM22 is the human homolog of Prpcwc2.
- Prpcwc26 or Bud13 belongs to the pre-mRNA retention and splicing complex RES.
Disease
Mutations in Prp8 and Prp31 cause retinitis pigmentosa[2].
3D Structures of pre-mRNA splicing factors
Updated on 10-July-2016
References
- ↑ Misteli T, Spector DL. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. Mol Cell. 1999 Jun;3(6):697-705. PMID:10394358
- ↑ McKie AB, McHale JC, Keen TJ, Tarttelin EE, Goliath R, van Lith-Verhoeven JJ, Greenberg J, Ramesar RS, Hoyng CB, Cremers FP, Mackey DA, Bhattacharya SS, Bird AC, Markham AF, Inglehearn CF. Mutations in the pre-mRNA splicing factor gene PRPC8 in autosomal dominant retinitis pigmentosa (RP13). Hum Mol Genet. 2001 Jul 15;10(15):1555-62. PMID:11468273
