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Pre-mRNA-splicing factor

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*Pre-mRNA-splicing factor 8
*Pre-mRNA-splicing factor 8
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**[[3sbt]], [[4ilh]] – yPrp RNAseH like domain + A1 cistron-splicing factor AAR2 – yeast<BR />
+
**[[3sbt]], [[4ilh]] – yPrp RNAseH like domain + A1 cistron-splicing factor AAR2 – yeast<br />
-
**[[4jk7]], [[4jk9]] - yPrp RNAseH like domain <br />
+
**[[4jk7]], [[4jk9]], [[3e9o]], [[3e9p]], [[3e66]] - yPrp RNA-binding domain <br />
-
**[[4ilj]], [[4jk8]], [[4jka]], [[4jkb]], [[4jkc]], [[4jkd]], [[4jke]], [[4jkf]], [[4jkg]], [[4jkh]] - yPrp RNAseH like domain (mutant)<br />
+
**[[4ilj]], [[4jk8]], [[4jka]], [[4jkb]], [[4jkc]], [[4jkd]], [[4jke]], [[4jkf]], [[4jkg]], [[4jkh]] - yPrp RNA-binding domain (mutant)<br />
-
**[[3e66]] – yPrp β-finger domain<BR />
+
-
**[[3e9o]], [[3e9p]] - yPrp RNA-binding domain<BR />
+
-
**[[2p87]], [[2og4]], [[3sbg]] - yPrp C terminal<BR />
+
**[[3zef]], [[4i43]] – yPrp + A1 cistron-splicing factor AAR2<br />
**[[3zef]], [[4i43]] – yPrp + A1 cistron-splicing factor AAR2<br />
-
**[[4bgd]] – yPrp JAB1/MPN domain + pre-mRNA-splicing helicase BRR2<br />
+
**[[2og4]], [[sbg]] - yPrp Jab1/MPN domain<br />
-
**[[4kit]] – yPrp JAB1/MPN domain + U5 small nuclear ribonucleoprotein helicase <br />
+
**[[4bgd]] – yPrp Jab1/MPN domain + pre-mRNA-splicing helicase BRR2<br />
-
**[[4ilg]] – yPrp JAB1/MPN+RNAseH domains + A1 cistron-splicing factor AAR2 <br />
+
**[[4kit]] – yPrp Jab1/MPN domain + U5 small nuclear ribonucleoprotein helicase <br />
-
**[[4bgd]] – yPrp JAB1/MPN+RNAseH domains + A1 cistron-splicing factor AAR2 + pre-mRNA-splicing helicase BRR2<br />
+
**[[4ilg]] – yPrp Jab1/MPN+RNA-binding domains + A1 cistron-splicing factor AAR2 <br />
-
**[[3lru]] – hPrp residues 1831-1990<BR />
+
**[[4bgd]] – yPrp Jab1/MPN+RNA-binding domains + A1 cistron-splicing factor AAR2 + pre-mRNA-splicing helicase BRR2<br />
-
**[[3e9l]] – hPrp endonuclease domain<BR />
+
**[[3lru]] – hPrp residues 1831-1990<br />
-
**[[3enb]] - hPrp core domain IV<BR />
+
**[[3e9l]], [[3enb]] – hPrp endonuclease domain<br />
-
**[[2p8r]] – Prp C terminal (mutant) – ''Caenorhabditis elegans''
+
**[[2p8r]] – CePrp C terminal (mutant) – ''Caenorhabditis elegans''<br />
 +
*[[2p87]] – CePrp C terminal <br />
*Pre-mRNA-splicing factor 9
*Pre-mRNA-splicing factor 9

Revision as of 08:52, 11 July 2016

Template:STRUCTURE 3e9l

Contents

Function

Pre-mRNA-splicing factors (Prp) are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing[1].

  • Prp3b is part of the U2 small nuclear ribonucleoproteins complex (U2 snRNP)
  • Prp8 functions as a scaffold which mediates the ordered assembly of spliceosomal proteins and snRNAs. For details see Prp8
  • Prp18 and Bud31 are essential for the catalytic step in pre-mRNA splicing process.
  • snRNA-associated-splicing factor 24 binds preferentially to the U4/U6 hybrid snRNAs. For details see Prp24
  • For Prp19 see Prp19
  • Prp31 functions in forming the U4/U5-U6 tri-snRNP.
  • For Prp40 see Prp40.
  • Prpcwc2 is a yeast splicing factor which plays a role in the generation of a functional splicing center Prp RBM22 is the human homolog of Prpcwc2.
  • Prpcwc26 or Bud13 belongs to the pre-mRNA retention and splicing complex RES.

Disease

Mutations in Prp8 and Prp31 cause retinitis pigmentosa[2].

3D Structures of pre-mRNA splicing factors

Updated on 11-July-2016



References

  1. ↑ Misteli T, Spector DL. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. Mol Cell. 1999 Jun;3(6):697-705. PMID:10394358
  2. ↑ McKie AB, McHale JC, Keen TJ, Tarttelin EE, Goliath R, van Lith-Verhoeven JJ, Greenberg J, Ramesar RS, Hoyng CB, Cremers FP, Mackey DA, Bhattacharya SS, Bird AC, Markham AF, Inglehearn CF. Mutations in the pre-mRNA splicing factor gene PRPC8 in autosomal dominant retinitis pigmentosa (RP13). Hum Mol Genet. 2001 Jul 15;10(15):1555-62. PMID:11468273

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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