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Pre-mRNA-splicing factor
From Proteopedia
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| - | + | <StructureSection load='3zef' size='350' side='right' caption='Yeast pre-mRNA-splicing factor 8 (green) complex with AAR2 (grey) (PDB entry [[3zef]])' scene=''> | |
| - | <StructureSection load='3zef' size='350' side='right' caption='Yeast pre-mRNA-splicing factor 8 complex with AAR2 (PDB entry [[3zef]])' scene=''> | + | |
== Function == | == Function == | ||
'''Pre-mRNA-splicing factors (Prp)''' are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing<ref>PMID:10394358</ref>. | '''Pre-mRNA-splicing factors (Prp)''' are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing<ref>PMID:10394358</ref>. | ||
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== Structural highlights == | == Structural highlights == | ||
| - | + | Prp8 is a multi-domain protein containing an RNA-binding domain and a Jab1/MPN domain. | |
</StructureSection> | </StructureSection> | ||
Revision as of 09:02, 11 July 2016
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3D Structures of pre-mRNA splicing factors
Updated on 11-July-2016
References
- ↑ Misteli T, Spector DL. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. Mol Cell. 1999 Jun;3(6):697-705. PMID:10394358
- ↑ McKie AB, McHale JC, Keen TJ, Tarttelin EE, Goliath R, van Lith-Verhoeven JJ, Greenberg J, Ramesar RS, Hoyng CB, Cremers FP, Mackey DA, Bhattacharya SS, Bird AC, Markham AF, Inglehearn CF. Mutations in the pre-mRNA splicing factor gene PRPC8 in autosomal dominant retinitis pigmentosa (RP13). Hum Mol Genet. 2001 Jul 15;10(15):1555-62. PMID:11468273
