4s0p

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'''Unreleased structure'''
 
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The entry 4s0p is ON HOLD until Jul 14 2017
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==Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (II)==
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<StructureSection load='4s0p' size='340' side='right' caption='[[4s0p]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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Authors: Priyadarshi, A., Gavathiotis, E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4s0p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S0P FirstGlance]. <br>
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Description: Autoinhibited Dimeric Form of Pro-apoptotic BAX (G67R)
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4s0o|4s0o]], [[1f16|1f16]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0p OCA], [http://pdbe.org/4s0p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s0p RCSB], [http://www.ebi.ac.uk/pdbsum/4s0p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Gavathiotis, E]]
[[Category: Gavathiotis, E]]
[[Category: Priyadarshi, A]]
[[Category: Priyadarshi, A]]
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[[Category: Apoptosis]]
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[[Category: Apoptosis regulator]]
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[[Category: Autoinhibited dimer]]
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[[Category: Bcl-2 family protein]]

Revision as of 15:23, 26 July 2016

Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (II)

4s0p, resolution 3.25Å

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