1jk8

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[[Image:1jk8.jpg|left|200px]]
[[Image:1jk8.jpg|left|200px]]
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{{Structure
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|PDB= 1jk8 |SIZE=350|CAPTION= <scene name='initialview01'>1jk8</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1jk8", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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{{STRUCTURE_1jk8| PDB=1jk8 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jk8 OCA], [http://www.ebi.ac.uk/pdbsum/1jk8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jk8 RCSB]</span>
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'''Crystal structure of a human insulin peptide-HLA-DQ8 complex'''
'''Crystal structure of a human insulin peptide-HLA-DQ8 complex'''
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[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
[[Category: Wucherpfennig, K W.]]
[[Category: Wucherpfennig, K W.]]
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[[Category: autoimmunity]]
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[[Category: Autoimmunity]]
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[[Category: hla-dq8]]
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[[Category: Hla-dq8]]
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[[Category: insulin b peptide]]
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[[Category: Insulin b peptide]]
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[[Category: type 1 diabetes]]
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[[Category: Type 1 diabetes]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:19:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:34:54 2008''
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Revision as of 18:19, 2 May 2008

Image:1jk8.jpg

Template:STRUCTURE 1jk8

Crystal structure of a human insulin peptide-HLA-DQ8 complex


Overview

The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2 in humans and I-A(g7) in nonobese diabetic (NOD) mice are the major risk factors for increased susceptibility to type 1 diabetes. Using X-ray crystallography, we have determined the three-dimensional structure of DQ8 complexed with an immunodominant peptide from insulin. The similarity of the DQ8, DQ2 and I-A(g7) peptide-binding pockets suggests that diabetes is caused by the same antigen-presentation event(s) in humans and NOD mice. Correlating type 1 diabetes epidemiology and MHC sequences with the DQ8 structure suggests that other structural features of the P9 pocket in addition to position 57 contribute to susceptibility to type 1 diabetes.

About this Structure

1JK8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes., Lee KH, Wucherpfennig KW, Wiley DC, Nat Immunol. 2001 Jun;2(6):501-7. PMID:11376336 Page seeded by OCA on Fri May 2 21:19:24 2008

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