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5i2c
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Arginine-bound CASTOR1 from Homo sapiens== | |
| - | + | <StructureSection load='5i2c' size='340' side='right' caption='[[5i2c]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5i2c]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I2C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i2c OCA], [http://pdbe.org/5i2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i2c RCSB], [http://www.ebi.ac.uk/pdbsum/5i2c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i2c ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GATL3_HUMAN GATL3_HUMAN]] Functions as an intracellular arginine sensor that regulates the TORC1 signaling pathway through the GATOR complex. As a homooligomer or a heterooligomer with GATSL2, directly binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of arginine to GATSL3 disrupts the interaction of GATSL3-containing oligomers with GATOR2 and activates the TORC1 signaling pathway.<ref>PMID:26972053</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Knockenhauer, K E]] | ||
| + | [[Category: Saxton, R A]] | ||
| + | [[Category: Schwartz, T U]] | ||
| + | [[Category: Act]] | ||
| + | [[Category: Arginine]] | ||
| + | [[Category: Mtor]] | ||
| + | [[Category: Signaling]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 16:26, 10 August 2016
Arginine-bound CASTOR1 from Homo sapiens
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Categories: Knockenhauer, K E | Saxton, R A | Schwartz, T U | Act | Arginine | Mtor | Signaling | Signaling protein
