5ke3
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a== | |
| - | + | <StructureSection load='5ke3' size='340' side='right' caption='[[5ke3]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ke3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KE3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KE3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6S5:(S)-N-(FURAN-2-YLMETHYL)-1-(1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBONYL)PIPERIDINE-4-CARBOXAMIDE'>6S5</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ke3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ke3 OCA], [http://pdbe.org/5ke3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ke3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ke3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ke3 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Brown, P J]] | ||
| + | [[Category: Dobrovetsky, E]] | ||
[[Category: Dong, A]] | [[Category: Dong, A]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Freitas, R Ferreira de]] | ||
| + | [[Category: Iqbal, A]] | ||
| + | [[Category: Mader, P]] | ||
| + | [[Category: Structural genomic]] | ||
[[Category: Schapira, M]] | [[Category: Schapira, M]] | ||
| - | + | [[Category: Walker, J R]] | |
| - | [[Category: Walker, J | + | [[Category: Inhibitor]] |
| - | [[Category: | + | [[Category: Methyl-lysine]] |
| - | [[Category: | + | [[Category: Setdb1]] |
| - | [[Category: | + | [[Category: Sgc]] |
| - | [[Category: | + | [[Category: Transcription-transcription inhibitor complex]] |
| - | [[Category: | + | [[Category: Tudor domain]] |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
Revision as of 04:19, 4 August 2016
Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a
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