This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1jmw
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1jmw.jpg|left|200px]] | [[Image:1jmw.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1jmw", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | | | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | + | --> | |
| - | + | {{STRUCTURE_1jmw| PDB=1jmw | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''Propagating Conformational Changes Over Long (And Short) Distances''' | '''Propagating Conformational Changes Over Long (And Short) Distances''' | ||
| Line 27: | Line 24: | ||
[[Category: Jr., D E.Koshland.]] | [[Category: Jr., D E.Koshland.]] | ||
[[Category: Yu, E W.]] | [[Category: Yu, E W.]] | ||
| - | [[Category: | + | [[Category: Bacterial chemotactic receptor]] |
| - | [[Category: | + | [[Category: Chemotaxis]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:26:00 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 18:26, 2 May 2008
Propagating Conformational Changes Over Long (And Short) Distances
Overview
The problem of the propagation of conformational changes over long distances or through a closely packed protein is shown to fit a model of a ligand-induced conformational change between two protein states selected by evolution. Moreover, the kinetics of the pathway between these states is also selected so that the energy of ligand binding and the speed of the transition between conformational states are physiologically appropriate. The crystallographic data of a wild-type aspartate receptor that has negative cooperativity and a mutant that has no cooperativity but has native transmembrane signaling are shown to support this model.
About this Structure
1JMW is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.
Reference
Propagating conformational changes over long (and short) distances in proteins., Yu EW, Koshland DE Jr, Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9517-20. PMID:11504940 Page seeded by OCA on Fri May 2 21:26:00 2008
