5lbw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human quinone reductase 2 (NQO2) in complex with volitinib== | |
| - | + | <StructureSection load='5lbw' size='340' side='right' caption='[[5lbw]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lbw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LBW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=V0L:volitinib'>V0L</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.5.1 1.10.5.1] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lbw OCA], [http://pdbe.org/5lbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lbw RCSB], [http://www.ebi.ac.uk/pdbsum/5lbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lbw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kuester, B]] | ||
[[Category: Medard, G]] | [[Category: Medard, G]] | ||
[[Category: Schneider, S]] | [[Category: Schneider, S]] | ||
| - | [[Category: | + | [[Category: Kinase inhibitor]] |
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Quinone reductase 2]] | ||
| + | [[Category: Ribosyldihydronicotinamide dehydrogenase]] | ||
| + | [[Category: Volitinib]] | ||
Revision as of 06:05, 29 November 2017
Structure of the human quinone reductase 2 (NQO2) in complex with volitinib
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