1jnx

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[[Image:1jnx.gif|left|200px]]
[[Image:1jnx.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1jnx |SIZE=350|CAPTION= <scene name='initialview01'>1jnx</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1jnx", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= BRCA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1jnx| PDB=1jnx | SCENE= }}
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|RELATEDENTRY=[[1cdz|1CDZ]], [[1imo|1IMO]], [[1in1|1IN1]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnx OCA], [http://www.ebi.ac.uk/pdbsum/1jnx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jnx RCSB]</span>
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}}
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'''Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1'''
'''Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1'''
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[[Category: Green, R.]]
[[Category: Green, R.]]
[[Category: Williams, R S.]]
[[Category: Williams, R S.]]
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[[Category: brct]]
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[[Category: Brct]]
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[[Category: cancer]]
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[[Category: Cancer]]
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[[Category: gene expression]]
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[[Category: Gene expression]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:28:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:36:21 2008''
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Revision as of 18:28, 2 May 2008

Image:1jnx.gif

Template:STRUCTURE 1jnx

Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1


Contents

Overview

The C-terminal BRCT region of BRCA1 is essential for its DNA repair, transcriptional regulation and tumor suppressor functions. Here we determine the crystal structure of the BRCT domain of human BRCA1 at 2.5 A resolution. The domain contains two BRCT repeats that adopt similar structures and are packed together in a head-to-tail arrangement. Cancer-causing missense mutations occur at the interface between the two repeats and destabilize the structure. The manner by which the two BRCT repeats interact in BRCA1 may represent a general mode of interaction between homologous domains within proteins that interact to regulate the cellular response to DNA damage. The structure provides a basis to predict the structural consequences of uncharacterized BRCA1 mutations.

Disease

Known disease associated with this structure: Breast cancer-1 OMIM:[113705], Breast-ovarian cancer OMIM:[113705], Ovarian cancer OMIM:[113705], Papillary serous carcinoma of the peritoneum OMIM:[113705]

About this Structure

1JNX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1., Williams RS, Green R, Glover JN, Nat Struct Biol. 2001 Oct;8(10):838-42. PMID:11573086 Page seeded by OCA on Fri May 2 21:28:47 2008

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OCA

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