1jof

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[[Image:1jof.jpg|left|200px]]
[[Image:1jof.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1jof |SIZE=350|CAPTION= <scene name='initialview01'>1jof</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1jof", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PIN:PIPERAZINE-N,N&#39;-BIS(2-ETHANESULFONIC+ACID)'>PIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxy-cis,cis-muconate_cyclase Carboxy-cis,cis-muconate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.5.1.5 5.5.1.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1jof| PDB=1jof | SCENE= }}
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|RELATEDENTRY=[[1muc|1MUC]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jof OCA], [http://www.ebi.ac.uk/pdbsum/1jof PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jof RCSB]</span>
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}}
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'''Neurospora crassa 3-carboxy-cis,cis-mucoante lactonizing enzyme'''
'''Neurospora crassa 3-carboxy-cis,cis-mucoante lactonizing enzyme'''
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[[Category: Merckel, M C.]]
[[Category: Merckel, M C.]]
[[Category: Thompson, A.]]
[[Category: Thompson, A.]]
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[[Category: beta-propeller]]
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[[Category: Beta-propeller]]
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[[Category: homotetramer]]
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[[Category: Homotetramer]]
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[[Category: semet-protein]]
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[[Category: Semet-protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:30:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:36:33 2008''
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Revision as of 18:30, 2 May 2008

Image:1jof.jpg

Template:STRUCTURE 1jof

Neurospora crassa 3-carboxy-cis,cis-mucoante lactonizing enzyme


Overview

Muconate lactonizing enzymes (MLEs) convert cis,cis-muconates to muconolactones in microbes as part of the beta-ketoadipate pathway; some also dehalogenate muconate derivatives of xenobiotic haloaromatics. There are three different MLE classes unrelated by evolution. We present the X-ray structure of a eukaryotic MLE, Neurospora crassa 3-carboxy-cis,cis-muconate lactonizing enzyme (NcCMLE) at 2.5 A resolution, with a seven-bladed beta propeller fold. It is related neither to bacterial MLEs nor to other beta propeller enzymes, but is structurally similar to the G protein beta subunit. It reveals a novel metal-independent cycloisomerase motif unlike the bacterial metal cofactor MLEs. Together, the bacterial MLEs and NcCMLE structures comprise a striking structural example of functional convergence in enzymes for 1,2-addition-elimination of carboxylic acids. NcCMLE and bacterial MLEs may enhance the reaction rate differently: the former by electrophilic catalysis and the latter by electrostatic stabilization of the enolate.

About this Structure

1JOF is a Single protein structure of sequence from Neurospora crassa. Full crystallographic information is available from OCA.

Reference

The structure of Neurospora crassa 3-carboxy-cis,cis-muconate lactonizing enzyme, a beta propeller cycloisomerase., Kajander T, Merckel MC, Thompson A, Deacon AM, Mazur P, Kozarich JW, Goldman A, Structure. 2002 Apr;10(4):483-92. PMID:11937053 Page seeded by OCA on Fri May 2 21:30:12 2008

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