1jpw
From Proteopedia
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'''Crystal Structure of a Human Tcf-4 / beta-Catenin Complex''' | '''Crystal Structure of a Human Tcf-4 / beta-Catenin Complex''' | ||
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[[Category: Poy, F.]] | [[Category: Poy, F.]] | ||
[[Category: Shivdasani, R A.]] | [[Category: Shivdasani, R A.]] | ||
| - | [[Category: | + | [[Category: Armadillo repeat]] |
| - | [[Category: | + | [[Category: Beta-catenin]] |
| - | [[Category: | + | [[Category: Colon cancer]] |
| - | [[Category: | + | [[Category: Tcf]] |
| - | [[Category: | + | [[Category: Tcf4]] |
| - | [[Category: | + | [[Category: Transcription factor]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:34:52 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 18:35, 2 May 2008
Crystal Structure of a Human Tcf-4 / beta-Catenin Complex
Overview
The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins, and the Wnt signal transduction pathway, where it interacts with the Adenomatous polyposis coli (APC) protein and TCF/Lef family transcription factors. Mutations in APC or in beta-catenin are estimated to trigger formation of over 90% of all colon cancers. In colonic epithelia, these mutations produce elevated levels of Tcf4-beta-catenin, which stimulates a transcriptional response that initiates polyp formation and eventually malignant growth. Thus, disruption of the Tcf4-beta-catenin interaction may be an attractive goal for therapeutic intervention. Here we describe the crystal structure of a human Tcf4-beta-catenin complex and compare it with recent structures of beta-catenin in complex with Xenopus Tcf3 (XTcf3) and mammalian E-cadherin. The structure reveals anticipated similarities with the closely related XTcf3 complex but unexpectedly lacks one component observed in the XTcf3 structure.
About this Structure
1JPW is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of a human Tcf4-beta-catenin complex., Poy F, Lepourcelet M, Shivdasani RA, Eck MJ, Nat Struct Biol. 2001 Dec;8(12):1053-7. PMID:11713476 Page seeded by OCA on Fri May 2 21:34:52 2008
