1jr3

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[[Image:1jr3.jpg|left|200px]]
[[Image:1jr3.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1jr3 |SIZE=350|CAPTION= <scene name='initialview01'>1jr3</scene>, resolution 2.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1jr3", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1jr3| PDB=1jr3 | SCENE= }}
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|RELATEDENTRY=[[1jqj|1JQJ]], [[1jql|1JQL]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr3 OCA], [http://www.ebi.ac.uk/pdbsum/1jr3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jr3 RCSB]</span>
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}}
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'''Crystal Structure of the Processivity Clamp Loader Gamma Complex of E. coli DNA Polymerase III'''
'''Crystal Structure of the Processivity Clamp Loader Gamma Complex of E. coli DNA Polymerase III'''
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[[Category: Jeruzalmi, D.]]
[[Category: Jeruzalmi, D.]]
[[Category: Kuriyan, J.]]
[[Category: Kuriyan, J.]]
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[[Category: aaa+ atpase]]
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[[Category: Aaa+ atpase]]
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[[Category: clamp loader]]
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[[Category: Clamp loader]]
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[[Category: dna polymerase]]
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[[Category: Dna polymerase]]
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[[Category: processivity]]
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[[Category: Processivity]]
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[[Category: processivity clamp]]
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[[Category: Processivity clamp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:43:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:37:45 2008''
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Revision as of 18:43, 2 May 2008

Image:1jr3.jpg

Template:STRUCTURE 1jr3

Crystal Structure of the Processivity Clamp Loader Gamma Complex of E. coli DNA Polymerase III


Overview

The gamma complex, an AAA+ ATPase, is the bacterial homolog of eukaryotic replication factor C (RFC) that loads the sliding clamp (beta, homologous to PCNA) onto DNA. The 2.7/3.0 A crystal structure of gamma complex reveals a pentameric arrangement of subunits, with stoichiometry delta':gamma(3):delta. The C-terminal domains of the subunits form a circular collar that supports an asymmetric arrangement of the N-terminal ATP binding domains of the gamma motor and the structurally related domains of the delta' stator and the delta wrench. The structure suggests a mechanism by which the gamma complex switches between a closed state, in which the beta-interacting element of delta is hidden by delta', and an open form similar to the crystal structure, in which delta is free to bind to beta.

About this Structure

1JR3 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase III., Jeruzalmi D, O'Donnell M, Kuriyan J, Cell. 2001 Aug 24;106(4):429-41. PMID:11525729 Page seeded by OCA on Fri May 2 21:43:05 2008

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