1jr1

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[[Image:1jr1.jpg|left|200px]]
[[Image:1jr1.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1jr1 |SIZE=350|CAPTION= <scene name='initialview01'>1jr1</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1jr1", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1jr1| PDB=1jr1 | SCENE= }}
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|RELATEDENTRY=[[1ak5|1AK5]], [[1b3o|1B3O]], [[1zfj|1ZFJ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [http://www.ebi.ac.uk/pdbsum/1jr1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB]</span>
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}}
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'''Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid'''
'''Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid'''
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[[Category: Sintchak, M D.]]
[[Category: Sintchak, M D.]]
[[Category: Wilson, K P.]]
[[Category: Wilson, K P.]]
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[[Category: dehydrogenase]]
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[[Category: Dehydrogenase]]
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[[Category: guanine nucleotide synthesis]]
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[[Category: Guanine nucleotide synthesis]]
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[[Category: impd]]
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[[Category: Impd]]
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[[Category: impdh]]
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[[Category: Impdh]]
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[[Category: mpa]]
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[[Category: Mpa]]
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[[Category: mycophenolic acid]]
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[[Category: Mycophenolic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:43:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:37:44 2008''
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Revision as of 18:43, 2 May 2008

Image:1jr1.jpg

Template:STRUCTURE 1jr1

Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid


Overview

The structure of inosine-5'-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction. IMPDH plays a central role in B and T lymphocyte replication. MPA is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug recently approved for the treatment of allograft rejection. IMPDH comprises two domains: a core domain, which is an alpha/beta barrel and contains the active site, and a flanking domain. The complex, in combination with mutagenesis and kinetic data, provides a structural basis for understanding the mechanism of IMPDH activity and indicates that MPA inhibits IMPDH by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule.

About this Structure

1JR1 is a Single protein structure of sequence from Cricetulus griseus. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid., Sintchak MD, Fleming MA, Futer O, Raybuck SA, Chambers SP, Caron PR, Murcko MA, Wilson KP, Cell. 1996 Jun 14;85(6):921-30. PMID:8681386 Page seeded by OCA on Fri May 2 21:43:05 2008

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