1jsc

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[[Image:1jsc.gif|left|200px]]
[[Image:1jsc.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1jsc |SIZE=350|CAPTION= <scene name='initialview01'>1jsc</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1jsc", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=2HP:DIHYDROGENPHOSPHATE+ION'>2HP</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetolactate_synthase Acetolactate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.2.1.6 2.2.1.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ILV2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_1jsc| PDB=1jsc | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jsc OCA], [http://www.ebi.ac.uk/pdbsum/1jsc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jsc RCSB]</span>
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}}
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'''Crystal Structure of the Catalytic Subunit of Yeast Acetohydroxyacid Synthase: A target for Herbicidal Inhibitors'''
'''Crystal Structure of the Catalytic Subunit of Yeast Acetohydroxyacid Synthase: A target for Herbicidal Inhibitors'''
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[[Category: Guddat, L W.]]
[[Category: Guddat, L W.]]
[[Category: Pang, S S.]]
[[Category: Pang, S S.]]
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[[Category: acetohydroxyacid synthase]]
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[[Category: Acetohydroxyacid synthase]]
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[[Category: acetolactate synthase]]
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[[Category: Acetolactate synthase]]
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[[Category: fad]]
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[[Category: Fad]]
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[[Category: herbicide inhibition]]
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[[Category: Herbicide inhibition]]
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[[Category: thiamin diphosphate]]
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[[Category: Thiamin diphosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:49:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:38:16 2008''
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Revision as of 18:49, 2 May 2008

Image:1jsc.gif

Template:STRUCTURE 1jsc

Crystal Structure of the Catalytic Subunit of Yeast Acetohydroxyacid Synthase: A target for Herbicidal Inhibitors


Overview

Acetohydroxyacid synthase (AHAS; EC 4.1.3.18) catalyzes the first step in branched-chain amino acid biosynthesis. The enzyme requires thiamin diphosphate and FAD for activity, but the latter is unexpected, because the reaction involves no oxidation or reduction. Due to its presence in plants, AHAS is a target for sulfonylurea and imidazolinone herbicides. Here, the crystal structure to 2.6 A resolution of the catalytic subunit of yeast AHAS is reported. The active site is located at the dimer interface and is near the proposed herbicide-binding site. The conformation of FAD and its position in the active site are defined. The structure of AHAS provides a starting point for the rational design of new herbicides.

About this Structure

1JSC is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors., Pang SS, Duggleby RG, Guddat LW, J Mol Biol. 2002 Mar 22;317(2):249-62. PMID:11902841 Page seeded by OCA on Fri May 2 21:49:56 2008

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