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1jsk

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[[Image:1jsk.gif|left|200px]]
[[Image:1jsk.gif|left|200px]]
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{{Structure
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|GENE= NKG2D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), RAE-1 Beta ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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{{STRUCTURE_1jsk| PDB=1jsk | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jsk OCA], [http://www.ebi.ac.uk/pdbsum/1jsk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jsk RCSB]</span>
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'''CRYSTAL STRUCTURE OF MURINE NK CELL LIGAND RAE-1 BETA IN COMPLEX WITH NKG2D'''
'''CRYSTAL STRUCTURE OF MURINE NK CELL LIGAND RAE-1 BETA IN COMPLEX WITH NKG2D'''
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[[Category: Li, P.]]
[[Category: Li, P.]]
[[Category: Strong, R K.]]
[[Category: Strong, R K.]]
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[[Category: immune system]]
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[[Category: Immune system]]
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[[Category: mhc-i platform]]
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[[Category: Mhc-i platform]]
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[[Category: murine nk cell ligand]]
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[[Category: Murine nk cell ligand]]
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[[Category: nkg2d]]
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[[Category: Nkg2d]]
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[[Category: rae-1 beta]]
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[[Category: Rae-1 beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:51:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:38:21 2008''
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Revision as of 18:51, 2 May 2008

Image:1jsk.gif

Template:STRUCTURE 1jsk

CRYSTAL STRUCTURE OF MURINE NK CELL LIGAND RAE-1 BETA IN COMPLEX WITH NKG2D


Overview

Induced by retinoic acid and implicated in playing a role in development, rodent RAE-1 proteins are ligands for the activating immunoreceptor NKG2D, widely expressed on natural killer cells, T cells, and macrophages. RAE-1 proteins (alpha, beta, gamma, and delta) are distant major histocompatibility complex (MHC) class I homologs, comprising isolated alpha1alpha2 platform domains. The crystal structure of RAE-1beta was distorted from other MHC homologs and displayed noncanonical disulfide bonds. The loss of any remnant of a peptide binding groove was facilitated by the close approach of the groove-defining helices through a hydrophobic, leucine-rich interface. The RAE-1beta-murine NKG2D complex structure resembled the human NKG2D-MICA receptor-ligand complex and further demonstrated the promiscuity of the NKG2D ligand binding site.

About this Structure

1JSK is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D., Li P, McDermott G, Strong RK, Immunity. 2002 Jan;16(1):77-86. PMID:11825567 Page seeded by OCA on Fri May 2 21:51:00 2008

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