1jss

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[[Image:1jss.gif|left|200px]]
[[Image:1jss.gif|left|200px]]
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{{Structure
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|PDB= 1jss |SIZE=350|CAPTION= <scene name='initialview01'>1jss</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1jss", creates the "Structure Box" on the page.
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|SITE=
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|GENE= BC005642; Unigene Cluster: Mm. 31508 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00177 START]</span>
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{{STRUCTURE_1jss| PDB=1jss | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jss OCA], [http://www.ebi.ac.uk/pdbsum/1jss PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jss RCSB]</span>
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'''Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4).'''
'''Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4).'''
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[[Category: Romanowski, M J.]]
[[Category: Romanowski, M J.]]
[[Category: Soccio, R E.]]
[[Category: Soccio, R E.]]
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[[Category: new york structural genomix research consortium]]
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[[Category: New york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: Nysgxrc]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: start domain]]
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[[Category: Start domain]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:51:34 2008''
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Revision as of 18:51, 2 May 2008

Image:1jss.gif

Template:STRUCTURE 1jss

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4).


Overview

The x-ray structure of the mouse cholesterol-regulated START protein 4 (StarD4) has been determined at 2.2-A resolution, revealing a compact alpha/beta structure related to the START domain present in the cytoplasmic C-terminal portion of human MLN64. The volume of the putative lipid-binding tunnel was estimated at 847 A(3), which is consistent with the binding of one cholesterol-size lipid molecule. Comparison of the tunnel-lining residues in StarD4 and MLN64-START permitted identification of possible lipid specificity determinants in both molecular tunnels. Homology modeling of related proteins, and comparison of the StarD4 and MLN64-START structures, showed that StarD4 is a member of a large START domain superfamily characterized by the helix-grip fold. Additional mechanistic and evolutionary studies should be facilitated by the availability of a second START domain structure from a distant relative of MLN64.

About this Structure

1JSS is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain., Romanowski MJ, Soccio RE, Breslow JL, Burley SK, Proc Natl Acad Sci U S A. 2002 May 14;99(10):6949-54. PMID:12011453 Page seeded by OCA on Fri May 2 21:51:34 2008

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