1jsu

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[[Image:1jsu.gif|left|200px]]
[[Image:1jsu.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1jsu| PDB=1jsu | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jsu OCA], [http://www.ebi.ac.uk/pdbsum/1jsu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jsu RCSB]</span>
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'''P27(KIP1)/CYCLIN A/CDK2 COMPLEX'''
'''P27(KIP1)/CYCLIN A/CDK2 COMPLEX'''
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[[Category: Pavletich, N P.]]
[[Category: Pavletich, N P.]]
[[Category: Russo, A A.]]
[[Category: Russo, A A.]]
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[[Category: cdk]]
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[[Category: Cdk]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: cell division]]
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[[Category: Cell division]]
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[[Category: complex (transferase/cyclin/inhibitor)]]
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[[Category: Cyclin]]
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[[Category: cyclin]]
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[[Category: Inhibitor]]
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[[Category: inhibitor]]
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[[Category: Kinase]]
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[[Category: kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:51:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:38:28 2008''
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Revision as of 18:51, 2 May 2008

Image:1jsu.gif

Template:STRUCTURE 1jsu

P27(KIP1)/CYCLIN A/CDK2 COMPLEX


Overview

The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom. p27Kip1 binds the complex as an extended structure interacting with both cyclin A and Cdk2. On cyclin A, it binds in a groove formed by conserved cyclin box residues. On Cdk2, it binds and rearranges the amino-terminal lobe and also inserts into the catalytic cleft, mimicking ATP.

About this Structure

1JSU is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex., Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP, Nature. 1996 Jul 25;382(6589):325-31. PMID:8684460 Page seeded by OCA on Fri May 2 21:51:51 2008

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