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5ipi

From Proteopedia

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'''Unreleased structure'''
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{{Large structure}}
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==Structure of Adeno-associated virus type 2 VLP==
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The entry 5ipi is ON HOLD until Paper Publication
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<StructureSection load='5ipi' size='340' side='right' caption='[[5ipi]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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== Structural highlights ==
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Authors:
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<table><tr><td colspan='2'>[[5ipi]] is a 60 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IPI FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ipk|5ipk]]</td></tr>
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Description:
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ipi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ipi OCA], [http://pdbe.org/5ipi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ipi RCSB], [http://www.ebi.ac.uk/pdbsum/5ipi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ipi ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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{{Large structure}}
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== Function ==
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[[http://www.uniprot.org/uniprot/CAPSD_AAV2S CAPSD_AAV2S]] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.<ref>PMID:10684294</ref> <ref>PMID:11961250</ref> <ref>PMID:16940508</ref> <ref>PMID:9445046</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Agbandje-McKenna, M]]
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[[Category: Baker, T S]]
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[[Category: Bennet, A]]
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[[Category: Cardone, G]]
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[[Category: Chen, W]]
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[[Category: Chipman, P]]
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[[Category: Drouin, L M]]
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[[Category: Janssen, M E]]
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[[Category: Lins, B]]
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[[Category: McKenna, R]]
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[[Category: Muzyczka, N]]
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[[Category: Adeno-associated virus]]
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[[Category: Dependoparvovirus]]
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[[Category: Gene therapy]]
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[[Category: Icosahedral]]
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[[Category: Virus like particle]]

Revision as of 15:39, 26 July 2016

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Structure of Adeno-associated virus type 2 VLP

5ipi, resolution 3.80Å

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