5k35
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the Legionella effector, AnkB, in complex with human Skp1== | |
| - | + | <StructureSection load='5k35' size='340' side='right' caption='[[5k35]], [[Resolution|resolution]] 2.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5k35]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K35 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K35 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5k34|5k34]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k35 OCA], [http://pdbe.org/5k35 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k35 RCSB], [http://www.ebi.ac.uk/pdbsum/5k35 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k35 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SKP1_HUMAN SKP1_HUMAN]] Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.<ref>PMID:16209941</ref> <ref>PMID:20181953</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Gehring, K]] | ||
| + | [[Category: Kozlov, G]] | ||
| + | [[Category: Wong, K]] | ||
| + | [[Category: Ankyrin repeat]] | ||
| + | [[Category: Bacterial effector]] | ||
| + | [[Category: Bsgi]] | ||
| + | [[Category: F-box protein]] | ||
| + | [[Category: Host-pathogen interaction]] | ||
| + | [[Category: Protein binding]] | ||
Revision as of 23:44, 25 January 2017
Structure of the Legionella effector, AnkB, in complex with human Skp1
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