1jvt

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[[Image:1jvt.gif|left|200px]]
[[Image:1jvt.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1jvt |SIZE=350|CAPTION= <scene name='initialview01'>1jvt</scene>, resolution 2.05&Aring;
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The line below this paragraph, containing "STRUCTURE_1jvt", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span>
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{{STRUCTURE_1jvt| PDB=1jvt | SCENE= }}
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|RELATEDENTRY=[[1jvu|1JVU]], [[1jvv|1JVV]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jvt OCA], [http://www.ebi.ac.uk/pdbsum/1jvt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jvt RCSB]</span>
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'''CRYSTAL STRUCTURE OF RIBONUCLEASE A (LIGAND-FREE FORM)'''
'''CRYSTAL STRUCTURE OF RIBONUCLEASE A (LIGAND-FREE FORM)'''
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[[Category: Vitagliano, L.]]
[[Category: Vitagliano, L.]]
[[Category: Zagari, A.]]
[[Category: Zagari, A.]]
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[[Category: protein dynamic]]
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[[Category: Protein dynamic]]
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[[Category: protein structure-function]]
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[[Category: Protein structure-function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:59:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:39:45 2008''
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Revision as of 18:59, 2 May 2008

Image:1jvt.gif

Template:STRUCTURE 1jvt

CRYSTAL STRUCTURE OF RIBONUCLEASE A (LIGAND-FREE FORM)


Overview

Despite the increasing number of successful determinations of complex protein structures the understanding of their dynamics properties is still rather limited. Using X-ray crystallography, we demonstrate that ribonuclease A (RNase A) undergoes significant domain motions upon ligand binding. In particular, when cytidine 2'-monophosphate binds to RNase A, the structure of the enzyme becomes more compact. Interestingly, our data also show that these structural alterations are fully reversible in the crystal state. These findings provide structural bases for the dynamic behavior of RNase A in the binding of the substrate shown by Petsko and coworkers (Rasmussen et al. Nature 1992;357:423-424). These subtle domain motions may assume functional relevance for more complex system and may play a significant role in the cooperativity of oligomeric enzymes.

About this Structure

1JVT is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Reversible substrate-induced domain motions in ribonuclease A., Vitagliano L, Merlino A, Zagari A, Mazzarella L, Proteins. 2002 Jan 1;46(1):97-104. PMID:11746706 Page seeded by OCA on Fri May 2 21:59:13 2008

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