1jwh

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[[Image:1jwh.jpg|left|200px]]
[[Image:1jwh.jpg|left|200px]]
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{{Structure
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|PDB= 1jwh |SIZE=350|CAPTION= <scene name='initialview01'>1jwh</scene>, resolution 3.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1jwh", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1jwh| PDB=1jwh | SCENE= }}
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|RELATEDENTRY=[[1daw|1DAW]], [[1day|1DAY]], [[1qf8|1QF8]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jwh OCA], [http://www.ebi.ac.uk/pdbsum/1jwh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jwh RCSB]</span>
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}}
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'''Crystal Structure of Human Protein Kinase CK2 Holoenzyme'''
'''Crystal Structure of Human Protein Kinase CK2 Holoenzyme'''
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[[Category: Issinger, O G.]]
[[Category: Issinger, O G.]]
[[Category: Niefind, K.]]
[[Category: Niefind, K.]]
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[[Category: casein kinase 2]]
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[[Category: Casein kinase 2]]
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[[Category: ck2 holoenzyme]]
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[[Category: Ck2 holoenzyme]]
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[[Category: protein kinase ck2]]
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[[Category: Protein kinase ck2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:00:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:40:01 2008''
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Revision as of 19:00, 2 May 2008

Image:1jwh.jpg

Template:STRUCTURE 1jwh

Crystal Structure of Human Protein Kinase CK2 Holoenzyme


Overview

The crystal structure of a fully active form of human protein kinase CK2 (casein kinase 2) consisting of two C-terminally truncated catalytic and two regulatory subunits has been determined at 3.1 A resolution. In the CK2 complex the regulatory subunits form a stable dimer linking the two catalytic subunits, which make no direct contact with one another. Each catalytic subunit interacts with both regulatory chains, predominantly via an extended C-terminal tail of the regulatory subunit. The CK2 structure is consistent with its constitutive activity and with a flexible role of the regulatory subunit as a docking partner for various protein kinases. Furthermore it shows an inter-domain mobility in the catalytic subunit known to be functionally important in protein kinases and detected here for the first time directly within one crystal structure.

About this Structure

1JWH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme., Niefind K, Guerra B, Ermakowa I, Issinger OG, EMBO J. 2001 Oct 1;20(19):5320-31. PMID:11574463 Page seeded by OCA on Fri May 2 22:00:36 2008

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