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1jxc

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[[Image:1jxc.gif|left|200px]]
[[Image:1jxc.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1jxc", creates the "Structure Box" on the page.
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|GENE= ATTp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])
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{{STRUCTURE_1jxc| PDB=1jxc | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxc OCA], [http://www.ebi.ac.uk/pdbsum/1jxc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jxc RCSB]</span>
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'''Minimized NMR structure of ATT, an Arabidopsis trypsin/chymotrypsin inhibitor'''
'''Minimized NMR structure of ATT, an Arabidopsis trypsin/chymotrypsin inhibitor'''
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[[Category: Markley, J L.]]
[[Category: Markley, J L.]]
[[Category: Zhao, Q.]]
[[Category: Zhao, Q.]]
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[[Category: att]]
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[[Category: Att]]
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[[Category: center for eukaryotic structural genomic]]
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[[Category: Center for eukaryotic structural genomic]]
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[[Category: cesg]]
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[[Category: Cesg]]
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[[Category: chymotrypsin inhibitor]]
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[[Category: Chymotrypsin inhibitor]]
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[[Category: hydrolase inhibitor]]
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[[Category: Hydrolase inhibitor]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: trypsin inhibitor]]
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[[Category: Trypsin inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:02:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:40:21 2008''
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Revision as of 19:02, 2 May 2008

Image:1jxc.gif

Template:STRUCTURE 1jxc

Minimized NMR structure of ATT, an Arabidopsis trypsin/chymotrypsin inhibitor


Overview

The three-dimensional structure of the precursor form of the Arabidopsis thaliana trypsin inhibitor (ATT(p), GenBank entry Z46816), a 68-residue (approximately 7.5 kDa) rapeseed class proteinase inhibitor, has been determined in solution at pH 5.0 and 25 degrees C by multinuclear magnetic resonance spectroscopy. The protein contains one alpha-helix and two strands of antiparallel beta-sheet, with a type IV beta-turn connecting the two strands. The alpha-helix and the inhibitory loop are connected to the beta-sheet through three disulfide bridges; a fourth disulfide bridge connects the N- and C-termini. The overall structural topology of ATT(p) is similar to those of the sweet tasting protein brazzein (rmsd of 3.0 A) and the antifungal protein Rs-Afp1 [a knottin protein from radish (Raphanus sativus), rmsd of 2.7 A]. The precursor segment in ATT(p) is disordered, as visualized by the final 20-conformer ensemble and as confirmed by (15)N heteronuclear NOE analysis. The overall fold of ATT(p) is distinct from those of other classes of serine proteinase inhibitors except in the inhibitor loop; therefore, it represents a new inhibitor fold.

About this Structure

1JXC is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

NMR solution structure of ATTp, an Arabidopsis thaliana trypsin inhibitor., Zhao Q, Chae YK, Markley JL, Biochemistry. 2002 Oct 15;41(41):12284-96. PMID:12369816 Page seeded by OCA on Fri May 2 22:02:23 2008

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