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1jy5

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[[Image:1jy5.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jy5 OCA], [http://www.ebi.ac.uk/pdbsum/1jy5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jy5 RCSB]</span>
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'''RNase-related protein from Calystegia sepium'''
'''RNase-related protein from Calystegia sepium'''
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[[Category: Rouge, P.]]
[[Category: Rouge, P.]]
[[Category: Verboven, C.]]
[[Category: Verboven, C.]]
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[[Category: alpha-beta protein]]
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[[Category: Alpha-beta protein]]
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[[Category: rnase]]
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[[Category: Rnase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:03:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:40:38 2008''
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Revision as of 19:03, 2 May 2008

Image:1jy5.gif

Template:STRUCTURE 1jy5

RNase-related protein from Calystegia sepium


Overview

The structure of a catalytically inactive RNase-related protein from Calystegia sepium (CalsepRRP) has been resolved by protein crystallography at a resolution of 2.05 A and an R factor of 20.74%. Although the protein is completely devoid of ribonuclease activity, it adopts the typical alpha + beta structure of non-base-specific RNases. Analysis of the structure revealed that two amino-acid substitutions in the 'active' P1 site, in combination with the less hydrophobic/aromatic character of the B1 base-recognition site and a completely disrupted B2 base-recognition site, might account for this complete lack of activity.

About this Structure

1JY5 is a Single protein structure of sequence from Calystegia sepium. Full crystallographic information is available from OCA.

Reference

Structure of an RNase-related protein from Calystegia sepium., Rabijns A, Verboven C, Rouge P, Barre A, Van Damme EJ, Peumans WJ, De Ranter CJ, Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):627-33. Epub 2002, Mar 22. PMID:11914487 Page seeded by OCA on Fri May 2 22:03:58 2008

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