2bwq
From Proteopedia
(New page: 200px<br /> <applet load="2bwq" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bwq, resolution 1.41Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BWQ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BWQ OCA]]. | + | 2BWQ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BWQ OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: transport protein]] | [[Category: transport protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:04:54 2007'' |
Revision as of 09:00, 30 October 2007
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CRYSTAL STRUCTURE OF THE RIM2 C2A-DOMAIN AT 1.4 ANGSTROM RESOLUTION
Overview
RIMs are large proteins that contain two C2-domains and are localized at, presynaptic active zones, where neurotransmitters are released. RIMs play, key roles in synaptic vesicle priming and regulation of presynaptic, plasticity. A mutation in the RIM1 C2A-domain has been implicated in, autosomal dominant cone-rod dystrophy (CORD7). The RIM C2A-domain does not, contain the full complement of aspartate residues that commonly mediate, Ca2+ binding at the top loops of C2-domains, and has been reported to, interact with SNAP-25 and synaptotagmin 1, two proteins from the, Ca2+-dependent membrane fusion machinery. Here we have used NMR, spectroscopy and X-ray crystallography to analyze the structure and, biochemical properties of the RIM2 C2A-domain, which is closely related to, the RIM1 ... [(full description)]
About this Structure
2BWQ is a [Single protein] structure of sequence from [Rattus norvegicus] with SO4 as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the RIM2 C2A-domain at 1.4 A resolution., Dai H, Tomchick DR, Garcia J, Sudhof TC, Machius M, Rizo J, Biochemistry. 2005 Oct 18;44(41):13533-42. PMID:16216076
Page seeded by OCA on Tue Oct 30 11:04:54 2007
