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| - | | + | #REDIRECT [[5xej]] This PDB entry is obsolete and replaced by 5xej |
| - | ==Crystal Structure of Macrophage Migration Inhibitory Factor bound to MTX==
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| - | <StructureSection load='5cg4' size='340' side='right' caption='[[5cg4]], [[Resolution|resolution]] 2.50Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[5cg4]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CG4 FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6UV:(2~{R})-2-[[4-[[2,4-BIS(AZANYL)PTERIDIN-6-YL]METHYL-METHYL-AMINO]PHENYL]CARBONYLAMINO]PENTANEDIOIC+ACID'>6UV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cg4 OCA], [http://pdbe.org/5cg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cg4 RCSB], [http://www.ebi.ac.uk/pdbsum/5cg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cg4 ProSAT]</span></td></tr>
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| - | </table>
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| - | == Disease ==
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| - | [[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Fukushima, K]]
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| - | [[Category: Drug discovery]]
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| - | [[Category: Isomerase-inhibitor complex]]
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| - | [[Category: Mif]]
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| - | [[Category: Rheumatoid arthritis]]
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