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1k09
From Proteopedia
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[[Image:1k09.jpg|left|200px]] | [[Image:1k09.jpg|left|200px]] | ||
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'''Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein''' | '''Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1K09 is a [[Protein complex]] structure | + | 1K09 is a [[Protein complex]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K09 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Carulla, N.]] | [[Category: Carulla, N.]] | ||
[[Category: Woodward, C.]] | [[Category: Woodward, C.]] | ||
| - | [[Category: | + | [[Category: Four-stranded antiparallel beta-sheet]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:08:25 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 19:08, 2 May 2008
Solution structure of BetaCore, A Designed Water Soluble Four-Stranded Antiparallel b-sheet Protein
Overview
BetaCore is a designed approximately 50-residue protein in which two BPTI-derived core modules, CM I and CM II, are connected by a 22-atom cross-link. At low temperature and pH 3, homo- and heteronuclear NMR data report a dominant folded ('f') conformation with well-dispersed chemical shifts, i, i+1 periodicity, numerous long-range NOEs, and slowed amide hydrogen isotope exchange patterns that is a four-stranded antiparallel beta-sheet with nonsymmetrical and specific association of CM I and CM II. BetaCore 'f' conformations undergo reversible, global, moderately cooperative, non-two-state thermal transitions to an equilibrium ensemble of unfolded 'u' conformations. There is a significant energy barrier between 'f' and 'u' conformations. This is the first designed four-stranded antiparallel beta-sheet that folds in water.
About this Structure
1K09 is a Protein complex structure. Full crystallographic information is available from OCA.
Reference
BetaCore, a designed water soluble four-stranded antiparallel beta-sheet protein., Carulla N, Woodward C, Barany G, Protein Sci. 2002 Jun;11(6):1539-51. PMID:12021452 Page seeded by OCA on Fri May 2 22:08:25 2008
