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1k1q

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[[Image:1k1q.gif|left|200px]]
[[Image:1k1q.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1k1q", creates the "Structure Box" on the page.
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|GENE= DBH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])
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{{STRUCTURE_1k1q| PDB=1k1q | SCENE= }}
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|RELATEDENTRY=[[1k1s|1K1S]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k1q OCA], [http://www.ebi.ac.uk/pdbsum/1k1q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k1q RCSB]</span>
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'''Crystal Structure of a DinB Family Error Prone DNA Polymerase from Sulfolobus solfataricus'''
'''Crystal Structure of a DinB Family Error Prone DNA Polymerase from Sulfolobus solfataricus'''
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[[Category: Silvian, L F.]]
[[Category: Silvian, L F.]]
[[Category: Toth, E A.]]
[[Category: Toth, E A.]]
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[[Category: dna polymerase]]
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[[Category: Dna polymerase]]
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[[Category: error-prone polymerase]]
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[[Category: Error-prone polymerase]]
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[[Category: lesion-bypass polymerase]]
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[[Category: Lesion-bypass polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:11:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:42:08 2008''
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Revision as of 19:11, 2 May 2008

Image:1k1q.gif

Template:STRUCTURE 1k1q

Crystal Structure of a DinB Family Error Prone DNA Polymerase from Sulfolobus solfataricus


Overview

A new group of error-prone DNA polymerases overcomes the blockage posed to normal DNA replication by damaged template bases, suggesting an active site with a loose, flexible pocket that accommodates aberrant DNA structures. We have determined a 2.8 A resolution crystal structure of the Sulfolobus solfataricus Dbh protein, a DNA translesion polymerase closely related to Escherichia coli DNA polymerase IV and human polymerase kappa. A high error rate is observed for the Dbh polymerase in a range of 10(-2)-10(-3) for all 12 base substitution mispairs. The crystal structure of Dbh reveals an overall architecture resembling other DNA polymerases but has unique features that are likely to contribute to error-prone synthesis, including -1 frameshifting mutations.

About this Structure

1K1Q is a Single protein structure of sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus., Silvian LF, Toth EA, Pham P, Goodman MF, Ellenberger T, Nat Struct Biol. 2001 Nov;8(11):984-9. PMID:11685247 Page seeded by OCA on Fri May 2 22:11:30 2008

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