1k1v
From Proteopedia
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'''Solution Structure of the DNA-Binding Domain of MafG''' | '''Solution Structure of the DNA-Binding Domain of MafG''' | ||
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[[Category: Tanaka, T.]] | [[Category: Tanaka, T.]] | ||
[[Category: Yamamoto, M.]] | [[Category: Yamamoto, M.]] | ||
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Revision as of 19:11, 2 May 2008
Solution Structure of the DNA-Binding Domain of MafG
Overview
The Maf family proteins, which constitute a subgroup of basic region-leucine zipper (bZIP) proteins, function as transcriptional regulators of cellular differentiation. Together with the basic region, the Maf extended homology region (EHR), conserved only within the Maf family, defines the DNA binding specific to Mafs. Here we present the first NMR-derived structure of the DNA-binding domain (residues 1-76) of MafG, which contains the EHR and the basic region. The structure consists of three alpha-helices and resembles the fold of the DNA-binding domain of Skn-1, a developmental transcription factor of Caenorhabditis elegans. The structural similarity between MafG and Skn-1 enables us to propose a possible mechanism by which Maf family proteins recognize their consensus DNA sequences.
About this Structure
1K1V is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Solution structure of the DNA-binding domain of MafG., Kusunoki H, Motohashi H, Katsuoka F, Morohashi A, Yamamoto M, Tanaka T, Nat Struct Biol. 2002 Apr;9(4):252-6. PMID:11875518 Page seeded by OCA on Fri May 2 22:11:47 2008
