1k24
From Proteopedia
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'''Crystal Structure of the OpcA Outer Membrane Adhesin/Invasin from Neisseria meningitidis''' | '''Crystal Structure of the OpcA Outer Membrane Adhesin/Invasin from Neisseria meningitidis''' | ||
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[[Category: Derrick, J P.]] | [[Category: Derrick, J P.]] | ||
[[Category: Prince, S M.]] | [[Category: Prince, S M.]] | ||
| - | [[Category: | + | [[Category: Adhesin]] |
| - | [[Category: | + | [[Category: Beta barrel]] |
| - | [[Category: | + | [[Category: Invasin]] |
| - | [[Category: | + | [[Category: Membrane protein]] |
| - | [[Category: | + | [[Category: Outer membrane]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:12:22 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 19:12, 2 May 2008
Crystal Structure of the OpcA Outer Membrane Adhesin/Invasin from Neisseria meningitidis
Overview
OpcA is an integral outer membrane protein from Neisseria meningitidis, the causative agent of meningococcal meningitis and septicemia. It mediates the adhesion of N. meningitidis to epithelial and endothelial cells by binding to vitronectin and proteoglycan cell-surface receptors. Here, we report the determination of the crystal structure of OpcA to 2.0 A resolution. OpcA adopts a 10-stranded beta-barrel structure with extensive loop regions that protrude above the predicted surface of the membrane. The second external loop adopts an unusual conformation, traversing the axis of the beta-barrel and apparently blocking formation of a pore through the membrane. Loops 2, 3, 4, and 5 associate to form one side of a crevice in the external surface of the structure, the other side being formed by loop 1. The crevice is lined by positively charged residues and would form an ideal binding site for proteoglycan polysaccharide. The structure, therefore, suggests a model for how adhesion of this important human pathogen to proteoglycan is mediated at the molecular level.
About this Structure
1K24 is a Single protein structure of sequence from Neisseria meningitidis. Full crystallographic information is available from OCA.
Reference
Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis., Prince SM, Achtman M, Derrick JP, Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3417-21. Epub 2002 Mar 12. PMID:11891340 Page seeded by OCA on Fri May 2 22:12:22 2008
