1k2y

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[[Image:1k2y.jpg|left|200px]]
[[Image:1k2y.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1k2y |SIZE=350|CAPTION= <scene name='initialview01'>1k2y</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_1k2y", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphomannomutase Phosphomannomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.8 5.4.2.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= AlgC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])
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-->
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|DOMAIN=
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{{STRUCTURE_1k2y| PDB=1k2y | SCENE= }}
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|RELATEDENTRY=[[1k35|1K35]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k2y OCA], [http://www.ebi.ac.uk/pdbsum/1k2y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k2y RCSB]</span>
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}}
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'''Crystal Structure of Phosphomannomutase/Phosphoglucomutase S108A mutant from P. aeruginosa'''
'''Crystal Structure of Phosphomannomutase/Phosphoglucomutase S108A mutant from P. aeruginosa'''
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[[Category: Regni, C.]]
[[Category: Regni, C.]]
[[Category: Tipton, P A.]]
[[Category: Tipton, P A.]]
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[[Category: active-site mutant]]
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[[Category: Active-site mutant]]
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[[Category: alpha/beta protein]]
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[[Category: Alpha/beta protein]]
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[[Category: enzyme-ligand complex]]
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[[Category: Enzyme-ligand complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:14:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:42:40 2008''
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Revision as of 19:14, 2 May 2008

Image:1k2y.jpg

Template:STRUCTURE 1k2y

Crystal Structure of Phosphomannomutase/Phosphoglucomutase S108A mutant from P. aeruginosa


Overview

The enzyme phosphomannomutase/phosphoglucomutase (PMM/PGM) from P. aeruginosa is required for the biosynthesis of two bacterial exopolysaccharides: alginate and lipopolysaccharide (LPS). Both of these molecules play a role in the virulence of P. aeruginosa, an important human pathogen known for its ability to develop antibiotic resistance and cause chronic lung infections in cystic fibrosis patients. The crystal structure of PMM/PGM shows that the enzyme has four domains, three of which have a similar three-dimensional fold. Residues from all four domains of the protein contribute to the formation of a large active site cleft in the center of the molecule. Detailed information on the active site of PMM/PGM lays the foundation for structure-based inhibitor design. Inhibitors of sufficient potency and specificity should impair the biosynthesis of alginate and LPS, and may facilitate clearance of the bacteria by the host immune system and increase the efficacy of conventional antibiotic treatment against chronic P. aeruginosa infections.

About this Structure

1K2Y is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Crystal structure of PMM/PGM: an enzyme in the biosynthetic pathway of P. aeruginosa virulence factors., Regni C, Tipton PA, Beamer LJ, Structure. 2002 Feb;10(2):269-79. PMID:11839312 Page seeded by OCA on Fri May 2 22:14:13 2008

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