5laq

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'''Unreleased structure'''
 
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The entry 5laq is ON HOLD until Paper Publication
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==Crystal structure of human phosphodiesterase 4B catalytic domain with inhibitor NPD-001==
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<StructureSection load='5laq' size='340' side='right' caption='[[5laq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors: Singh, A.K., Brown, D.G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5laq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LAQ FirstGlance]. <br>
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Description: Crystal structure of human phosphodiesterase 4B catalytic domain with inhibitor NPD-001
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6M5:(4~{a}~{S},8~{a}~{R})-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(1~{H}-1,2,3,4-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-one'>6M5</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5g57|5g57]], [[5g2b|5g2b]], [[5l8c|5l8c]], [[5l9h|5l9h]], [[5g5v|5g5v]], [[5l8y|5l8y]]</td></tr>
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[[Category: Brown, D.G]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5laq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5laq OCA], [http://pdbe.org/5laq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5laq RCSB], [http://www.ebi.ac.uk/pdbsum/5laq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5laq ProSAT]</span></td></tr>
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[[Category: Singh, A.K]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Brown, D G]]
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[[Category: Singh, A K]]
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[[Category: Alternative splicing]]
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[[Category: Camp]]
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[[Category: Hydrolase]]
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[[Category: Phosphodiesterase]]

Revision as of 06:17, 14 March 2018

Crystal structure of human phosphodiesterase 4B catalytic domain with inhibitor NPD-001

5laq, resolution 2.40Å

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