5laq
From Proteopedia
(Difference between revisions)
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- | '''Unreleased structure''' | ||
- | + | ==Crystal structure of human phosphodiesterase 4B catalytic domain with inhibitor NPD-001== | |
- | + | <StructureSection load='5laq' size='340' side='right' caption='[[5laq]], [[Resolution|resolution]] 2.40Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[5laq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LAQ FirstGlance]. <br> | |
- | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6M5:(4~{a}~{S},8~{a}~{R})-2-cycloheptyl-4-[4-methoxy-3-[4-[4-(1~{H}-1,2,3,4-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-one'>6M5</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
- | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5g57|5g57]], [[5g2b|5g2b]], [[5l8c|5l8c]], [[5l9h|5l9h]], [[5g5v|5g5v]], [[5l8y|5l8y]]</td></tr> |
- | [[Category: Brown, D | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5laq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5laq OCA], [http://pdbe.org/5laq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5laq RCSB], [http://www.ebi.ac.uk/pdbsum/5laq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5laq ProSAT]</span></td></tr> |
- | [[Category: Singh, A | + | </table> |
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref> | ||
+ | == References == | ||
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Brown, D G]] | ||
+ | [[Category: Singh, A K]] | ||
+ | [[Category: Alternative splicing]] | ||
+ | [[Category: Camp]] | ||
+ | [[Category: Hydrolase]] | ||
+ | [[Category: Phosphodiesterase]] |
Revision as of 06:17, 14 March 2018
Crystal structure of human phosphodiesterase 4B catalytic domain with inhibitor NPD-001
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