1k40

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[[Image:1k40.gif|left|200px]]
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{{Structure
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|PDB= 1k40 |SIZE=350|CAPTION= <scene name='initialview01'>1k40</scene>, resolution 2.25&Aring;
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The line below this paragraph, containing "STRUCTURE_1k40", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k40 OCA], [http://www.ebi.ac.uk/pdbsum/1k40 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k40 RCSB]</span>
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'''crystal structure of the FAT domain of focal adhesion kinase'''
'''crystal structure of the FAT domain of focal adhesion kinase'''
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[[Category: Liddington, R C.]]
[[Category: Liddington, R C.]]
[[Category: Vuori, K.]]
[[Category: Vuori, K.]]
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[[Category: helix bundle]]
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[[Category: Helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:16:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:43:03 2008''
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Revision as of 19:16, 2 May 2008

Template:STRUCTURE 1k40

crystal structure of the FAT domain of focal adhesion kinase


Overview

Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localizing FAK to focal adhesions. We have determined the crystal structure of FAT and show that it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not. We show by mutagenesis that paxillin binding involves two hydrophobic patches on opposite faces of the bundle and propose a model in which two LD motifs of paxillin adopt amphipathic helices that augment the hydrophobic core of FAT, creating a six-helix bundle.

About this Structure

1K40 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin., Hayashi I, Vuori K, Liddington RC, Nat Struct Biol. 2002 Feb;9(2):101-6. PMID:11799401 Page seeded by OCA on Fri May 2 22:16:40 2008

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