1k40
From Proteopedia
Line 1: | Line 1: | ||
[[Image:1k40.gif|left|200px]] | [[Image:1k40.gif|left|200px]] | ||
- | + | <!-- | |
- | + | The line below this paragraph, containing "STRUCTURE_1k40", creates the "Structure Box" on the page. | |
- | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
- | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
- | + | or leave the SCENE parameter empty for the default display. | |
- | | | + | --> |
- | | | + | {{STRUCTURE_1k40| PDB=1k40 | SCENE= }} |
- | + | ||
- | + | ||
- | }} | + | |
'''crystal structure of the FAT domain of focal adhesion kinase''' | '''crystal structure of the FAT domain of focal adhesion kinase''' | ||
Line 29: | Line 26: | ||
[[Category: Liddington, R C.]] | [[Category: Liddington, R C.]] | ||
[[Category: Vuori, K.]] | [[Category: Vuori, K.]] | ||
- | [[Category: | + | [[Category: Helix bundle]] |
- | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:16:40 2008'' | |
- | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + |
Revision as of 19:16, 2 May 2008
crystal structure of the FAT domain of focal adhesion kinase
Overview
Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localizing FAK to focal adhesions. We have determined the crystal structure of FAT and show that it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not. We show by mutagenesis that paxillin binding involves two hydrophobic patches on opposite faces of the bundle and propose a model in which two LD motifs of paxillin adopt amphipathic helices that augment the hydrophobic core of FAT, creating a six-helix bundle.
About this Structure
1K40 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin., Hayashi I, Vuori K, Liddington RC, Nat Struct Biol. 2002 Feb;9(2):101-6. PMID:11799401 Page seeded by OCA on Fri May 2 22:16:40 2008