This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1k5j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1k5j.gif|left|200px]]
[[Image:1k5j.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1k5j |SIZE=350|CAPTION= <scene name='initialview01'>1k5j</scene>, resolution 2.30&Aring;
+
The line below this paragraph, containing "STRUCTURE_1k5j", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= Nucleoplasmin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 Xenopus laevis])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1k5j| PDB=1k5j | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k5j OCA], [http://www.ebi.ac.uk/pdbsum/1k5j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k5j RCSB]</span>
+
-
}}
+
'''The Crystal Structure of Nucleoplasmin-Core'''
'''The Crystal Structure of Nucleoplasmin-Core'''
Line 34: Line 31:
[[Category: Laue, T.]]
[[Category: Laue, T.]]
[[Category: Nolte, R T.]]
[[Category: Nolte, R T.]]
-
[[Category: beta-barrel]]
+
[[Category: Beta-barrel]]
-
[[Category: beta-bulge]]
+
[[Category: Beta-bulge]]
-
[[Category: jellyroll]]
+
[[Category: Jellyroll]]
-
[[Category: pentamer]]
+
[[Category: Pentamer]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:20:12 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:43:45 2008''
+

Revision as of 19:20, 2 May 2008

Image:1k5j.gif

Template:STRUCTURE 1k5j

The Crystal Structure of Nucleoplasmin-Core


Overview

The efficient assembly of histone complexes and nucleosomes requires the participation of molecular chaperones. Currently, there is a paucity of data on their mechanism of action. We now present the structure of an N-terminal domain of nucleoplasmin (Np-core) at 2.3 A resolution. The Np-core monomer is an eight-stranded beta barrel that fits snugly within a stable pentamer. In the crystal, two pentamers associate to form a decamer. We show that both Np and Np-core are competent to assemble large complexes that contain the four core histones. Further experiments and modeling suggest that these complexes each contain five histone octamers which dock to a central Np decamer. This work has important ramifications for models of histone storage, sperm chromatin decondensation, and nucleosome assembly.

About this Structure

1K5J is a Single protein structure of sequence from Xenopus laevis. The following page contains interesting information on the relation of 1K5J with [Importins]. Full crystallographic information is available from OCA.

Reference

The crystal structure of nucleoplasmin-core: implications for histone binding and nucleosome assembly., Dutta S, Akey IV, Dingwall C, Hartman KL, Laue T, Nolte RT, Head JF, Akey CW, Mol Cell. 2001 Oct;8(4):841-53. PMID:11684019 Page seeded by OCA on Fri May 2 22:20:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k5j"
Personal tools