1k5w

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[[Image:1k5w.jpg|left|200px]]
[[Image:1k5w.jpg|left|200px]]
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{{Structure
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|PDB= 1k5w |SIZE=350|CAPTION= <scene name='initialview01'>1k5w</scene>
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The line below this paragraph, containing "STRUCTURE_1k5w", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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{{STRUCTURE_1k5w| PDB=1k5w | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k5w OCA], [http://www.ebi.ac.uk/pdbsum/1k5w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k5w RCSB]</span>
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'''THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE'''
'''THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE'''
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[[Category: Sudhof, T C.]]
[[Category: Sudhof, T C.]]
[[Category: Ubach, J.]]
[[Category: Ubach, J.]]
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[[Category: c2-domain]]
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[[Category: C2-domain]]
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[[Category: c2b-domain]]
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[[Category: C2b-domain]]
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[[Category: calcium-binding]]
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[[Category: Calcium-binding]]
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[[Category: neurotransmitter release]]
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[[Category: Neurotransmitter release]]
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[[Category: phospholipid-binding]]
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[[Category: Phospholipid-binding]]
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[[Category: synapsis]]
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[[Category: Synapsis]]
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[[Category: synaptic vesicle exocytosis]]
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[[Category: Synaptic vesicle exocytosis]]
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[[Category: synaptotagmin i]]
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[[Category: Synaptotagmin i]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:21:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:43:55 2008''
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Revision as of 19:21, 2 May 2008

Image:1k5w.jpg

Template:STRUCTURE 1k5w

THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE


Overview

Synaptotagmin 1 probably functions as a Ca2+ sensor in neurotransmitter release via its two C2-domains, but no common Ca2+-dependent activity that could underlie a cooperative action between them has been described. The NMR structure of the C2B-domain now reveals a beta sandwich that exhibits striking similarities and differences with the C2A-domain. Whereas the bottom face of the C2B-domain has two additional alpha helices that may be involved in specialized Ca2+-independent functions, the top face binds two Ca2+ ions and is remarkably similar to the C2A-domain. Consistent with these results, but in contrast to previous studies, we find that the C2B-domain binds phospholipids in a Ca2+-dependent manner similarly to the C2A-domain. These results suggest a novel view of synaptotagmin function whereby the two C2-domains cooperate in a common activity, Ca2+-dependent phospholipid binding, to trigger neurotransmitter release.

About this Structure

1K5W is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine., Fernandez I, Arac D, Ubach J, Gerber SH, Shin O, Gao Y, Anderson RG, Sudhof TC, Rizo J, Neuron. 2001 Dec 20;32(6):1057-69. PMID:11754837 Page seeded by OCA on Fri May 2 22:21:01 2008

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