5jo8
From Proteopedia
(Difference between revisions)
| Line 6: | Line 6: | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jo8 OCA], [http://pdbe.org/5jo8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jo8 RCSB], [http://www.ebi.ac.uk/pdbsum/5jo8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jo8 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jo8 OCA], [http://pdbe.org/5jo8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jo8 RCSB], [http://www.ebi.ac.uk/pdbsum/5jo8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jo8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Dysfunction of cilia is associated with common genetic disorders termed ciliopathies. Knowledge on the interaction networks of ciliary proteins is therefore key for understanding the processes that are underlying these severe diseases and the mechanisms of ciliogenesis in general. Cep104 has recently been identified as a key player in the regulation of cilia formation. Using a combination of sequence analysis, biophysics, and x-ray crystallography, we obtained new insights into the domain architecture and interaction network of the Cep104 protein. We solved the crystal structure of the tumor overexpressed gene (TOG) domain, identified Cep104 as a novel tubulin-binding protein, and biophysically characterized the interaction of Cep104 with CP110, Cep97, end-binding (EB) protein, and tubulin. Our results represent a solid platform for the further investigation of the microtubule-EB-Cep104-tubulin-CP110-Cep97 network of proteins. Ultimately, such studies should be of importance for understanding the process of cilia formation and the mechanisms underlying different ciliopathies. | ||
| + | |||
| + | Biophysical and Structural Characterization of the Centriolar Protein Cep104 Interaction Network.,Rezabkova L, Kraatz SH, Akhmanova A, Steinmetz MO, Kammerer RA J Biol Chem. 2016 Aug 26;291(35):18496-504. doi: 10.1074/jbc.M116.739771. Epub, 2016 Jul 8. PMID:27402853<ref>PMID:27402853</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5jo8" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 05:26, 9 September 2016
CEP104 TOG domain
| |||||||||||
