1k6z

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[[Image:1k6z.jpg|left|200px]]
[[Image:1k6z.jpg|left|200px]]
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{{Structure
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|PDB= 1k6z |SIZE=350|CAPTION= <scene name='initialview01'>1k6z</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1k6z", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= SycE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 Yersinia pestis])
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|DOMAIN=
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{{STRUCTURE_1k6z| PDB=1k6z | SCENE= }}
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|RELATEDENTRY=[[1huf|1HUF]], [[1g9u|1G9U]], [[1jl5|1JL5]], [[1jyo|1JYO]], [[1k3e|1K3E]], [[1k3s|1K3S]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6z OCA], [http://www.ebi.ac.uk/pdbsum/1k6z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k6z RCSB]</span>
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'''Crystal Structure of the Yersinia Secretion Chaperone SycE'''
'''Crystal Structure of the Yersinia Secretion Chaperone SycE'''
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[[Category: Tropea, J E.]]
[[Category: Tropea, J E.]]
[[Category: Waugh, D S.]]
[[Category: Waugh, D S.]]
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[[Category: chaperone]]
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[[Category: Chaperone]]
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[[Category: secretion]]
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[[Category: Secretion]]
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[[Category: toxin]]
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[[Category: Toxin]]
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[[Category: yersinia pesti]]
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[[Category: Yersinia pesti]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:23:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:44:18 2008''
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Revision as of 19:23, 2 May 2008

Image:1k6z.jpg

Template:STRUCTURE 1k6z

Crystal Structure of the Yersinia Secretion Chaperone SycE


Overview

Many bacterial pathogens utilize a type III (contact-dependent) secretion system to inject cytotoxic effector proteins directly into host cells. This ingenious mechanism, designed for both bacterial offense and defense, has been studied most extensively in Yersinia spp. To be exported efficiently, at least three of the effectors (YopE, YopH and YopT) and several other proteins that transit the type III secretion pathway in Yersinia (YopN, YopD and YopB) must first form transient complexes with cognate-specific Yop chaperone (Syc) proteins. The cytotoxic effector YopE, a selective activator of mammalian Rho-family GTPases, associates with SycE. Here, the structure of Y. pestis SycE at 1.95A resolution is reported. SycE possesses a novel fold with an unusual dimerization motif and an intriguing basic cavity located on the dyad axis of the dimer that may participate in its interaction with YopE.

About this Structure

1K6Z is a Single protein structure of sequence from Yersinia pestis. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the type III secretion chaperone SycE from Yersinia pestis., Evdokimov AG, Tropea JE, Routzahn KM, Waugh DS, Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):398-406. Epub 2002, Feb 21. PMID:11856824 Page seeded by OCA on Fri May 2 22:23:02 2008

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