5j28
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Ki67-PP1g (protein phosphatase 1, gamma isoform) holoenzyme complex== | |
| - | + | <StructureSection load='5j28' size='340' side='right' caption='[[5j28]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5j28]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J28 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5inb|5inb]], [[5ioh|5ioh]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j28 OCA], [http://pdbe.org/5j28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j28 RCSB], [http://www.ebi.ac.uk/pdbsum/5j28 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j28 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PP1G_HUMAN PP1G_HUMAN]] Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.<ref>PMID:17936702</ref> <ref>PMID:20516061</ref> [[http://www.uniprot.org/uniprot/KI67_HUMAN KI67_HUMAN]] Thought to be required for maintaining cell proliferation. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Phosphoprotein phosphatase]] | ||
| + | [[Category: Kumar, G S]] | ||
| + | [[Category: Page, R]] | ||
| + | [[Category: Peti, W]] | ||
| + | [[Category: Hydrolase-protein binding complex]] | ||
| + | [[Category: Ki-67]] | ||
| + | [[Category: Phosphatase]] | ||
| + | [[Category: Pp1 gamma]] | ||
| + | [[Category: Repoman]] | ||
Revision as of 21:29, 5 October 2016
Ki67-PP1g (protein phosphatase 1, gamma isoform) holoenzyme complex
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