5kwn
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The WD domain ofArabidopsis thaliana E3 Ubiquitin Ligase COP1 in complex with peptide from HY5== |
| - | + | <StructureSection load='5kwn' size='340' side='right' caption='[[5kwn]], [[Resolution|resolution]] 1.42Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5kwn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KWN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kwn OCA], [http://pdbe.org/5kwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kwn RCSB], [http://www.ebi.ac.uk/pdbsum/5kwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kwn ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/COP1_ARATH COP1_ARATH]] E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways.<ref>PMID:11967090</ref> <ref>PMID:12023303</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Blacklow, S]] | ||
| + | [[Category: Uljon, S]] | ||
| + | [[Category: Ligase-peptide complex]] | ||
| + | [[Category: Photomorphogenesis e3 ligase wd domain transcription factor]] | ||
Revision as of 09:19, 1 November 2017
The WD domain ofArabidopsis thaliana E3 Ubiquitin Ligase COP1 in complex with peptide from HY5
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