5lk5
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the globular domain of human calreticulin mutant D71K== | |
| - | + | <StructureSection load='5lk5' size='340' side='right' caption='[[5lk5]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lk5]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LK5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pow|3pow]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lk5 OCA], [http://pdbe.org/5lk5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lk5 RCSB], [http://www.ebi.ac.uk/pdbsum/5lk5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lk5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CALR_HUMAN CALR_HUMAN]] Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).<ref>PMID:7876246</ref> <ref>PMID:11149926</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cioci, G]] | ||
[[Category: Gaboriaud, C]] | [[Category: Gaboriaud, C]] | ||
| - | [[Category: | + | [[Category: Calcium-binding protein]] |
Revision as of 14:03, 10 September 2016
Crystal structure of the globular domain of human calreticulin mutant D71K
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