Purine nucleoside phosphorylase
From Proteopedia
(Difference between revisions)
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**[[1odk]], [[1odl]] – TtPNP – ''Thermus thermophilus'' <br /> | **[[1odk]], [[1odl]] – TtPNP – ''Thermus thermophilus'' <br /> | ||
**[[1z33]] – TvPNP – ''Trichomonas vaginalis''<br /> | **[[1z33]] – TvPNP – ''Trichomonas vaginalis''<br /> | ||
| - | **[[1tcv]], [[1td1]] – SmPNP – ''Schistosoma masoni''<br /> | + | **[[1tcv]], [[1td1]], [[5cxs]] – SmPNP – ''Schistosoma masoni''<br /> |
**[[2b94]] – PNP – ''Plasmodium knowlesi'' <br /> | **[[2b94]] – PNP – ''Plasmodium knowlesi'' <br /> | ||
**[[4mar]] – MrPNP – ''Meiothermus ruber''<br /> | **[[4mar]] – MrPNP – ''Meiothermus ruber''<br /> | ||
| - | **[[1ecp]], [[1oty]], [[1ou4]], [[1yqq]], [[1yqu]], [[1yr3]], [[3onv]], [[4rj2]] – EcPNP – ''Escherichia coli'' <br /> | + | **[[1ecp]], [[1oty]], [[1ou4]], [[1yqq]], [[1yqu]], [[1yr3]], [[3onv]], [[4rj2]], [[4ts3]], [[4ts9]] – EcPNP – ''Escherichia coli'' <br /> |
| - | **[[1otx]], [[1oum]], [[1ov6]], [[3opv]] – EcPNP (mutant)<br /> | + | **[[1otx]], [[1oum]], [[1ov6]], [[3opv]], [[4tta]], [[4tti]], [[4ttj]] – EcPNP (mutant)<br /> |
**[[1vhj]] – VcPNP – ''Vibrio cholerae''<br /> | **[[1vhj]] – VcPNP – ''Vibrio cholerae''<br /> | ||
**[[1xe3]] – PNP – ''Bacillus anthracis''<br /> | **[[1xe3]] – PNP – ''Bacillus anthracis''<br /> | ||
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**[[4ldn]] – PNP + phosphate – ''Vibrio fischeri''<br /> | **[[4ldn]] – PNP + phosphate – ''Vibrio fischeri''<br /> | ||
**[[4m7w]] – PNP + phosphate – ''Leptotrichia buccalis''<br /> | **[[4m7w]] – PNP + phosphate – ''Leptotrichia buccalis''<br /> | ||
| + | **[[5mx4]], [[5mx6]], [[5mx8]], [[5lu0]] - PNP + phosphate - ''Helicobacter pylori''<br /> | ||
*Purine nucleoside phosphorylase complex with guanine and guanine derivatives | *Purine nucleoside phosphorylase complex with guanine and guanine derivatives | ||
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**[[1vmk]] – PNP + guanine – ''Thermotoga maritima'' <br /> | **[[1vmk]] – PNP + guanine – ''Thermotoga maritima'' <br /> | ||
**[[3iom]] – MtPNP + guanine derivative - ''Mycobacterium tuberculosis'' <br /> | **[[3iom]] – MtPNP + guanine derivative - ''Mycobacterium tuberculosis'' <br /> | ||
| + | **[[5i3c]] - EcPNP + guanine derivative <br /> | ||
**[[1b8n]] – bPNP + guanine derivative + phosphate<br /> | **[[1b8n]] – bPNP + guanine derivative + phosphate<br /> | ||
**[[1c3x]] – CePNP + guanine derivative + phosphate<br /> | **[[1c3x]] – CePNP + guanine derivative + phosphate<br /> | ||
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**[[2bsx]] – PfPNP + inosine – ''Plasmodium falciparum''<br /> | **[[2bsx]] – PfPNP + inosine – ''Plasmodium falciparum''<br /> | ||
**[[1z39]] – TvPNP + deoxyinosine <br /> | **[[1z39]] – TvPNP + deoxyinosine <br /> | ||
| - | **[[1a9t]], [[1a9p]] – bPNP + deazainosine + phosphate<br /> | + | **[[1a9t]], [[1a9p]], [[4pnp]] – bPNP + deazainosine + phosphate<br /> |
**[[1pr0]] - EcPNP + inosine + phosphate<br /> | **[[1pr0]] - EcPNP + inosine + phosphate<br /> | ||
**[[1v3q]] – hPNP + anti HIV drug <br /> | **[[1v3q]] – hPNP + anti HIV drug <br /> | ||
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**[[4dab]] – BsPNP + hypoxanthine<br /> | **[[4dab]] – BsPNP + hypoxanthine<br /> | ||
**[[4uc0]] – PNP + hypoxanthine – ''Agrobacterium vitis''<br /> | **[[4uc0]] – PNP + hypoxanthine – ''Agrobacterium vitis''<br /> | ||
| + | **[[5ifk]] - PNP + hypoxanthine - ''Kluyveromyces lactis''<br /> | ||
**[[3enz]] – PfPNP + hypoxanthine + ribose + arsenate<br /> | **[[3enz]] – PfPNP + hypoxanthine + ribose + arsenate<br /> | ||
**[[2a0w]], [[2a0x]], [[2a0y]], [[2oc4]], [[2oc9]] – hPNP (mutant) + hypoxanthine derivative <br /> | **[[2a0w]], [[2a0x]], [[2a0y]], [[2oc4]], [[2oc9]] – hPNP (mutant) + hypoxanthine derivative <br /> | ||
| + | **[[5iu6]] - EcPNP + hypoxanthine derivative<br /> | ||
**[[3odg]] – YpPNP + xanthine – ''Yersinia pseudotuberculosis''<br /> | **[[3odg]] – YpPNP + xanthine – ''Yersinia pseudotuberculosis''<br /> | ||
**[[1b8o]], [[1g2o]] – bPNP + hypoxanthine derivative + phosphate<br /> | **[[1b8o]], [[1g2o]] – bPNP + hypoxanthine derivative + phosphate<br /> | ||
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**[[3d1v]] – hPNP + mercapto-quinazolinone<br /> | **[[3d1v]] – hPNP + mercapto-quinazolinone<br /> | ||
| + | **[[5etj]], [[5ugf]] - hPNP (mutant) + inhibitor + phosphate<br /> | ||
**[[1z36]] – TvPNP + antibiotic<br /> | **[[1z36]] – TvPNP + antibiotic<br /> | ||
**[[3djf]] – SmPNP + inhibitor<br /> | **[[3djf]] – SmPNP + inhibitor<br /> | ||
**[[3e0q]] – SmPNP + pyrimidine derivative<br /> | **[[3e0q]] – SmPNP + pyrimidine derivative<br /> | ||
**[[3fb1]] – SmPNP + ribose-1-phosphate <br /> | **[[3fb1]] – SmPNP + ribose-1-phosphate <br /> | ||
| + | **[[5ko5]] - SmPNP + cytosine<br /> | ||
| + | **[[5ko6]] - SmPNP + cytosine + ribose-1-phosphate<br /> | ||
**[[1a69]], [[1pr1]] – EcPNP + formycin <br /> | **[[1a69]], [[1pr1]] – EcPNP + formycin <br /> | ||
**[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br /> | **[[1k9s]], [[3ut6]] – EcPNP + formycin derivative + phosphate<br /> | ||
Revision as of 21:59, 21 September 2017
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3D structures of purine nucleoside phosphorylase
Updated on 21-September-2017
References
- ↑ Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349-425. PMID:11337031
- ↑ Markert ML. Purine nucleoside phosphorylase deficiency. Immunodefic Rev. 1991;3(1):45-81. PMID:1931007
- ↑ de Azevedo WF Jr, Canduri F, dos Santos DM, Pereira JH, Bertacine Dias MV, Silva RG, Mendes MA, Basso LA, Palma MS, Santos DS. Crystal structure of human PNP complexed with guanine. Biochem Biophys Res Commun. 2003 Dec 19;312(3):767-72. PMID:14680831 doi:10.1016/j.bbrc.2003.10.190
