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5lkl
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of full-lengh CSFV NS3/4A== | |
| - | + | <StructureSection load='5lkl' size='340' side='right' caption='[[5lkl]], [[Resolution|resolution]] 3.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lkl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LKL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LKL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lkl OCA], [http://pdbe.org/5lkl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lkl RCSB], [http://www.ebi.ac.uk/pdbsum/5lkl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lkl ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/POLG_CSFVA POLG_CSFVA]] E(rns), E1 and E2 are responsible of cell attachment and subsequent fusion of viral and cellular membrane. P7 forms a leader sequence to properly orient NS2 in the membrane. Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.[PROSITE-ProRule:PRU01029] NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity. RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.[PROSITE-ProRule:PRU00539] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Rey, F A]] | ||
| + | [[Category: Tortorici, M A]] | ||
| + | [[Category: Viral protease/helicase with its cofactor]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 23:44, 25 January 2017
Crystal Structure of full-lengh CSFV NS3/4A
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