1khw

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[[Image:1khw.jpg|left|200px]]
[[Image:1khw.jpg|left|200px]]
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{{Structure
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|PDB= 1khw |SIZE=350|CAPTION= <scene name='initialview01'>1khw</scene>, resolution 2.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1khw", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span>
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1khw| PDB=1khw | SCENE= }}
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|RELATEDENTRY=[[1khv|1KHV]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1khw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1khw OCA], [http://www.ebi.ac.uk/pdbsum/1khw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1khw RCSB]</span>
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}}
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'''Crystal Structure of Rabbit Hemorrhagic Disease Virus RNA-dependent RNA polymerase complexed with Mn2+'''
'''Crystal Structure of Rabbit Hemorrhagic Disease Virus RNA-dependent RNA polymerase complexed with Mn2+'''
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[[Category: Parra, F.]]
[[Category: Parra, F.]]
[[Category: Vazquez, A L.]]
[[Category: Vazquez, A L.]]
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[[Category: rna-dependent rna polymerase]]
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[[Category: Rna-dependent rna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:46:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:48:50 2008''
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Revision as of 19:46, 2 May 2008

Image:1khw.jpg

Template:STRUCTURE 1khw

Crystal Structure of Rabbit Hemorrhagic Disease Virus RNA-dependent RNA polymerase complexed with Mn2+


Overview

The structure of the RNA-dependent RNA polymerase (RdRP) from the rabbit hemorrhagic disease virus has been determined by x-ray crystallography to a 2.5-A resolution. The overall structure resembles a "right hand," as seen before in other polymerases, including the RdRPs of polio virus and hepatitis C virus. Two copies of the polymerase are present in the asymmetric unit of the crystal, revealing active and inactive conformations within the same crystal form. The fingers and palm domains form a relatively rigid unit, but the thumb domain can adopt either "closed" or "open" conformations differing by a rigid body rotation of approximately 8 degrees. Metal ions bind at different positions in the two conformations and suggest how structural changes may be important to enzymatic function in RdRPs. Comparisons between the structures of the alternate conformational states of rabbit hemorrhagic disease virus RdRP and the structures of RdRPs from hepatitis C virus and polio virus suggest novel structure-function relationships in this medically important class of enzymes.

About this Structure

1KHW is a Single protein structure of sequence from Rabbit hemorrhagic disease virus. Full crystallographic information is available from OCA.

Reference

Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase., Ng KK, Cherney MM, Vazquez AL, Machin A, Alonso JM, Parra F, James MN, J Biol Chem. 2002 Jan 11;277(2):1381-7. Epub 2001 Oct 24. PMID:11677245 Page seeded by OCA on Fri May 2 22:46:05 2008

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